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Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
Although humans have been exposed to airborne nanosized particles (NSPs; < 100 nm) throughout their evolutionary stages, such exposure has increased dramatically over the last century due toExpand
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Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy
AbstractThe rapid proliferation of many different engineered nanomaterials (defined as materials designed and produced to have structural features with at least one dimension of 100 nanometers orExpand
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Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies
Characterizing the state of nanoparticles (such as size, surface charge, and degree of agglomeration) in aqueous suspensions and understanding the parameters that affect this state are imperative forExpand
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Translocation of Inhaled Ultrafine Manganese Oxide Particles to the Central Nervous System
Background Studies in monkeys with intranasally instilled gold ultrafine particles (UFPs; < 100 nm) and in rats with inhaled carbon UFPs suggested that solid UFPs deposited in the nose travel alongExpand
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Ultrafine Particle Deposition in Humans During Rest and Exercise
Ultrafine particles (diameter < 100 nm) may be important in the health effects of air pollution, in part because of their predicted high respiratory deposition. However, there are few measurements ofExpand
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Studies with intravenously injected ultrafine particles have shown that the liver is the major organ of their uptake from the blood circulation. Measuring translocation of inhaled ultrafine particlesExpand
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Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology.
Exposure to high concentrations of carbon black (Cb) produces lung tumors in rats, but not mice or hamsters, presumably due to secondary genotoxic mechanisms involving persistent lung inflammationExpand
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Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs
Currently, translocation of inhaled insoluble nanoparticles (NP) across membranes like the air-blood barrier into secondary target organs (STOs) is debated. Of key interest are the involvedExpand
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Chronic inhalation of fibrous and nonfibrous particles by rats at high concentrations results in lung tumor formation if the particles are poorly soluble in the lung. Even rather benign nonfibrousExpand
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Nanoparticles and the brain: cause for concern?.
Engineered nanoparticles (NPs) are in the same size category as atmospheric ultrafine particles, < 100 nm. Per given volume, both have high numbers and surface areas compared to larger particles. TheExpand
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