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The Antineoplastic Lectin of the Common Edible Mushroom (Agaricus bisporus) Has Two Binding Sites, Each Specific for a Different Configuration at a Single Epimeric Hydroxyl*
- M. E. Carrizo, S. Capaldi, M. Perduca, F. Irazoqui, G. Nores, H. Monaco
- Chemistry, Medicine
- Journal of Biological Chemistry
- 18 March 2005
The lectin from the common mushroom Agaricus bisporus, the most popular edible species in Western countries, has potent antiproliferative effects on human epithelial cancer cells, without any… Expand
Density-dependent recognition of cell surface GM3 by a certain anti-melanoma antibody, and GM3 lactone as a possible immunogen: requirements for tumor-associated antigen and immunogen.
A mouse monoclonal antibody M2590, previously established after immunization of mice (C57BL/6) with syngeneic melanoma B16 cells and showing preferential reactivity with various types of melanoma… Expand
An IgG3 monoclonal antibody established after immunization with GM3 lactone: immunochemical specificity and inhibition of melanoma cell growth in vitro and in vivo.
Immunization with lactone forms of tumor-associated ganglioside antigens might be useful in the production of antibodies and prevention of tumor cell growth in vivo (antitumor vaccines). Expand
Correlative fine specificity of several Thomsen-Friedenreich disaccharide-binding proteins with an effect on tumor cell proliferation.
Findings indicate that TFD-binding proteins that stimulate the proliferation of epithelial tumor cell lines recognize mainly a terminal beta-Gal region of beta-linked TFD, whereas ABL, which inhibits the growth of these tumor cells, binds mainly to subterminal GalNAc of alpha-anomeric TFD. Expand
Synthesis and characterization of lyso-GM3 (II3Neu5Ac Lactosyl sphingosine), de-N-acetyl-GM3 (II3NeuNH2 lactosyl Cer), and related compounds.
- G. Nores, N. Hanai, S. Levery, H. Eaton, E. K. Salyan, S. Hakomori
- Chemistry, Medicine
- Carbohydrate research
- 15 August 1988
Various GM3 derivatives which are present in A431 cells have different effects on the activity of the EGF receptor kinase and these effects have been synthesized in order to systematically study these effects. Expand
A novel ganglioside, de-N-acetyl-GM3 (II3NeuNH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth.
- N. Hanai, T. Dohi, G. Nores, S. Hakomori
- Medicine, Biology
- The Journal of biological chemistry
- 5 May 1988
Data indicate that de-N-acetylation at the sialic acid moiety of GM3 ganglioside is an important mechanism for modulation of EGF-dependent cell growth. Expand
Characterization of anti-ganglioside antibodies present in normal human plasma
It is postulate that the anti-GM1/GD1b immunoreactivity present in normal human plasma could be a cross-reaction of antibodies originally directed to a GA1-like carbohydrate structure. Expand
Glycosphingolipids in insects. The amphoteric moiety, N-acetylglucosamine-linked phosphoethanolamine, distinguishes a group of ceramide oligosaccharides from the pupae of Calliphora vicina (Insecta:…
- F. Helling, R. Dennis, +5 authors H. Wiegandt
- Biology, Medicine
- European journal of biochemistry
- 1 September 1991
A group of Calliphora vicina pupal glycolipids could be segregated from the neutral glycosphingolipids, according to their two-dimensional TLC migration properties and positive reactions toward… Expand
Chromatographic tank designed to obtain highly reproducible high-performance thin-layer chromatograms of gangliosides and neutral glycosphingolipids
Abstract Although high-performance thin-layer chromatography (HPTLC) is one of the most useful methods in glycosphingolipid studies, there are some difficulties with the reproducibility of the… Expand
High affinity as a disease determinant factor in anti-GM1 antibodies: comparative characterization of experimentally induced vs. disease-associated antibodies
The results suggest the existence of a threshold value above which affinity of anti-GM(1) antibodies becomes an important factor in disease induction, and the absence of neuropathy symptoms in rabbits may be explained by absence of these high-affinity anti- GM( 1) antibodies. Expand