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Lung function in early adulthood and health in later life: a transgenerational cohort analysis.
BACKGROUND Early life events can affect health in later life. We hypothesised that low lung function (FEV1 <80% predicted) in early adulthood (25-40 years) is associated with higher prevalence and… Expand
Network Analysis of Lung Transcriptomics Reveals a Distinct B-Cell Signature in Emphysema.
- R. Faner, T. Cruz, +9 authors A. Agustí
- American journal of respiratory and critical care…
- 1 June 2016
RATIONALE Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation caused by a combination of airways disease (bronchiolitis) and parenchymal destruction… Expand
From systems biology to P4 medicine: applications in respiratory medicine
Human health and disease are emergent properties of a complex, nonlinear, dynamic multilevel biological system: the human body. Systems biology is a comprehensive research strategy that has the… Expand
Multi-level differential network analysis of COPD exacerbations
Patients with chronic obstructive pulmonary disease (COPD) often suffer episodes of exacerbation (ECOPD) that impact negatively the course of their disease. ECOPD are heterogeneous events of unclear… Expand
The antiproliferative effect of pinostrobin on human umbilical vein endothelial cells (HUVEC).
- T. Siekmann, K. M. Burgazlı, M. Bobrich, G. Noell, A. Erdoğan
- Biology, Medicine
- European review for medical and pharmacological…
- 1 March 2013
BACKGROUND Atherosclerosis and stent re-stenosis are problems that are accompanied with high morbidity and mortality. Endothelial cell proliferation plays a role in both diseases, so the quest for… Expand
Bone marrow characterization in COPD: a multi-level network analysis
BackgroundBone marrow (BM) produces hematopoietic and progenitor cells that contribute to distant organ inflammation and repair. Chronic obstructive pulmonary disease (COPD) is characterized by… Expand
Distribution, temporal stability and association with all-cause mortality of the 2017 GOLD groups in the ECLIPSE cohort.
BACKGROUND In 2017, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) proposed a new classification of patients with chronic obstructive pulmonary disease (COPD). MATERIAL AND… Expand
The EASI model: A first integrative computational approximation to the natural history of COPD
The natural history of chronic obstructive pulmonary disease (COPD) is still not well understood. Traditionally believed to be a self-inflicted disease by smoking, now we know that not all smokers… Expand
Smoking Impairs the Immunomodulatory Capacity of Lung Resident Mesenchymal Stem Cells in COPD.
- T. Cruz, Alejandra López-Giraldo, +7 authors R. Faner
- American journal of respiratory cell and…
- 1 November 2019
Tobacco smoking is the main environmental risk factor of Chronic Obstructive Pulmonary Disease (COPD), but not all smokers develop the disease. A population of lung resident mesenchymal stem cells… Expand
Multi-level immune response network in mild-moderate Chronic Obstructive Pulmonary Disease (COPD)
BackgroundChronic Obstructive Pulmonary Disease (COPD) is associated with an abnormal pulmonary and systemic immune response to tobacco smoking. Yet, how do immune cells relate within and between… Expand