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Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells
Aims/hypothesisWe explored the potential adverse effects of pro-atherogenic oxidised LDL-cholesterol particles on beta cell function.Materials and methodsIsolated human and rat islets and differentExpand
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Role for inducible cAMP early repressor in promoting pancreatic beta cell dysfunction evoked by oxidative stress in human and rat islets
Aims/hypothesisPro-atherogenic and pro-oxidant, oxidised LDL trigger adverse effects on pancreatic beta cells, possibly contributing to diabetes progression. Because oxidised LDL diminish theExpand
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Exendin-4 Protects β-Cells From Interleukin-1β–Induced Apoptosis by Interfering With the c-Jun NH2-Terminal Kinase Pathway
OBJECTIVE— The pro-inflammatory cytokine interleukin-1β (IL-1β) generates pancreatic β-cells apoptosis mainly through activation of the c-Jun NH2-terminal kinase (JNK) pathway. This study wasExpand
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The Repressor Element Silencing Transcription Factor (REST)-mediated Transcriptional Repression Requires the Inhibition of Sp1*
The terminal differentiation of neuronal and pancreatic β-cells requires the specific expression of genes that are targets of an important transcriptional repressor named RE-1 silencing transcriptionExpand
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Complexin I regulates glucose-induced secretion in pancreatic β-cells
The neuronal-specific protein complexin I (CPX I) plays an important role in controlling the Ca2+-dependent neurotransmitter release. Since insulin exocytosis and neurotransmitter release rely onExpand
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The hairy and enhancer of split 1 is a negative regulator of the repressor element silencer transcription factor
Silencing of the transcriptional repressor REST is required for terminal differentiation of neuronal and β‐cells. In this study, we hypothesized that REST expression is controlled by hairy andExpand
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The Transcriptional Repressor REST Determines the Cell-Specific Expression of the Human MAPK8IP1 Gene Encoding IB1 (JIP-1)
ABSTRACT Islet-brain 1 (IB1) is the human and rat homologue of JIP-1, a scaffold protein interacting with the c-Jun amino-terminal kinase (JNK). IB1 expression is mostly restricted to the endocrineExpand
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Complexin I regulates glucose-induced secretion in pancreatic beta-cells.
The neuronal-specific protein complexin I (CPX I) plays an important role in controlling the Ca(2+)-dependent neurotransmitter release. Since insulin exocytosis and neurotransmitter release rely onExpand
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Neuronal traits are required for glucose‐induced insulin secretion
The transcriptional repressor RE1 silencer transcription factor (REST) is an important factor that restricts some neuronal traits to neurons. Since these traits are also present in pancreaticExpand
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The mif gene is transcriptionally regulated by glucose in insulin-secreting cells.
Macrophage migration inhibitory factor (MIF) is an important regulator of glucose homeostasis. In pancreatic beta-cells, MIF expression is regulated by glucose and its secretion potentiates theExpand
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