• Publications
  • Influence
Anti-inflammatory Effect of Resveratrol and Polydatin by In Vitro IL-17 Modulation
Interleukin-17 (IL-17) is a proinflammatory cytokine produced, although not exclusively, by T helper 17 recently identified as a distinct T helper lineage mediating tissue inflammation. IL-17 isExpand
  • 100
  • 1
  • Open Access
Phospho-TCTP as a therapeutic target of dihydroartemisinin for aggressive breast cancer cells
Upregulation of Translationally Controlled Tumor Protein (TCTP) is associated with poorly differentiated aggressive tumors, including breast cancer, but the underlying mechanism(s) are still debated.Expand
  • 29
  • 1
  • Open Access
WNT-pathway components as predictive markers useful for diagnosis, prevention and therapy in inflammatory bowel disease and sporadic colorectal cancer
The key role of the Wnt/β-catenin signaling in colorectal cancer (CRC) insurgence and progression is now recognized and several therapeutic strategies targeting this pathway are currently inExpand
  • 42
  • 1
  • Open Access
Rapid Chagas diagnosis in clinical settings using a multiparametric assay.
The development of an immunoassay for detecting circulating antibodies against Trypanosoma cruzi with a good performance appears to be crucial in clinical settings for the management of ChagasExpand
  • 2
Developing drugs that target the Wnt pathway: recent approaches in cancer and neurodegenerative diseases
ABSTRACT Introduction: Wnt/β-catenin signaling is an evolutionarily conserved pathway that has a crucial role in embryonic and adult life. Dysregulation of Wnt/β-catenin pathway has been associatedExpand
  • 21
Regulatory framework on bioequivalence criteria for locally acting gastrointestinal drugs: the case for oral modified release mesalamine formulations
ABSTRACT Introduction: Bioequivalence testing for locally acting gastrointestinal drugs is a challenging issue for both regulatory authorities and pharmaceutical industries. The internationalExpand
  • 2
  • Open Access
Atrial Natriuretic Peptide Acts as a Neuroprotective Agent in in Vitro Models of Parkinson’s Disease via Up-regulation of the Wnt/β-Catenin Pathway
In the last decades increasing evidence indicated a crucial role of the Wnt/β-catenin signaling in development of midbrain dopaminergic (mDA) neurons. Recently dysregulation of this pathway has beenExpand
  • 6
  • Open Access
In vitro evaluation of the wound healing activity of Drypetes klainei stem bark extracts.
ETHNOPHARMACOLOGICAL RELEVANCE Drypetes klainei Pierre ex Pax is used in Cameroon by Baka Pygmies in the wound healing process and for the treatment of burns. AIM OF THE STUDY To validate theExpand
  • 6
The Iterative Development of Medicines Through the European Medicine Agency's Adaptive Pathway Approach
The development of novel regulatory tools such as adaptive clinical trial design and utilization of real-world evidence are topics of high interest. Recently, the European Medicines Agency (EMA)Expand
  • 4
  • Open Access
Suspected adverse drug reactions (ADRs) trends in older Italian patients: an analysis from the National Pharmacovigilance Network
The clinical management of older populations is a social and clinical challenge. These subjects are more vulnerable to adverse drug reactions (ADRs) due to multi morbidity, polypharmacy, andExpand
  • 2