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Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.
The landscape of spider-venom peptides that have so far been described to target vertebrate or invertebrate Na(V) channels are reviewed, with some of these peptides having become useful pharmacological tools, while others have potential as therapeutic leads because they target specific Na( V) channel subtypes that are considered to be important analgesic targets.
ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures
Key features of ArachnoServer include a molecular target ontology designed specifically for venom toxins, current and historic taxonomic information and a powerful advanced search interface.
A rational nomenclature for naming peptide toxins from spiders and other venomous animals.
A rational nomenclature is introduced that can be applied to the naming of peptide toxins from spiders and other venomous animals to enable these toxins to be rationally classified, catalogued, and compared.
Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge.
We have isolated a family of insect-selective neurotoxins from the venom of the Australian funnel-web spider that appear to be good candidates for biopesticide engineering. These peptides, which we
Spider-Venom Peptides as Bioinsecticides
The structure and pharmacology of many newly characterized insecticidal spider toxins target novel sites in insects and the potential of this vast peptide library for the discovery of novel bioinsecticides is discussed.
Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function
This review examines the sources, structures and pharmacology of ciguatoxins, attention is placed on their cellular modes of actions to modulate voltage-gated ion channels and other Na+-dependent mechanisms in numerous cell types and to current approaches for detection and treatment of Ciguatera.
Venomics: unravelling the complexity of animal venoms with mass spectrometry.
The combined application of LC-MALDI separation with mass fingerprinting and ISD fragmentation for the determination of structural and pharmacological classes of peptides in complex spider venoms serves as the basis for the full investigation of complex spider venom proteomes, in combination with cDNA analysis.
Insect-selective spider toxins targeting voltage-gated sodium channels.
  • G. Nicholson
  • Biology, Medicine
    Toxicon : official journal of the International…
  • 15 March 2007
A number of peptide neurotoxins from the venoms of araneomorph and mygalomorph spiders have been isolated and characterized and determined to interact with several of these sites, and may provide tools to establish the molecular determinants of invertebrate selectivity.
Unravelling the complex venom landscapes of lethal Australian funnel-web spiders (Hexathelidae: Atracinae) using LC-MALDI-TOF mass spectrometry.
Inter- and intra-species venom complexity in 18 samples collected from a variety of lethal Australian funnel-web spiders using C4 reversed-phase separation coupled to offline MALDI-TOF mass spectrometry is investigated, highlighting both the utility of LC-MALDI-toF in spider taxonomy and the massive combinatorial peptide libraries that spider venoms offer the pharmaceutical and agrochemical industry.
Clinical and in vitro evidence for the efficacy of Australian red-back spider (Latrodectus hasselti) antivenom in the treatment of envenomation by a Cupboard spider (Steatoda grossa).
Red-back spider antivenom (RBSAV) is likely to be effective in reversing symptoms of envenomation and should be considered in the treatment of patients with distressing or persisting symptoms.