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Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis.
Follistatin is known to antagonise the function of several members of the TGF-beta family of secreted signalling factors, including Myostatin, the most powerful inhibitor of muscle growthExpand
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Effect of milking frequency and pasture intake on milk yield and composition of late lactation cows.
Twenty-four monozygous twinsets in late lactation (> 210 d in milk) were used to examine the effects of feed restriction and milking frequency prior to drying off on milk yield and composition in aExpand
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Titin-cap associates with, and regulates secretion of, Myostatin.
Myostatin, a secreted growth factor, is a key negative regulator of skeletal muscle growth. To identify modifiers of Myostatin function, we screened for Myostatin interacting proteins. Using a yeastExpand
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Milk L-lactate concentration is increased during mastitis.
A study was undertaken in cattle to evaluate changes in milk L-lactate in relation to mastitis. A healthy, rear quarter of the udder of each of ten cows in mid-lactation was infused with 1000Expand
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Proteolytic processing of myostatin is auto-regulated during myogenesis.
Myostatin, a potent negative regulator of myogenesis, is proteolytically processed by furin proteases into active mature myostatin before secretion from myoblasts. Here, we show that mature myostatinExpand
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Effects of stage of lactation and time of year on plasmin-derived proteolytic activity in bovine milk in New Zealand.
The objective of this study was to determine the effects of stage of lactation (SOL) and time of year on plasmin-derived proteolytic activity in the milk of pasture-fed dairy cows in New Zealand.Expand
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Antagonism of myostatin enhances muscle regeneration during sarcopenia.
A reduction in muscle mass and strength is often observed with aging, and this phenomenon is known as sarcopenia. This age-related atrophy frequently correlates with insufficient levels of muscleExpand
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Actions of Short-Term Fasting on Human Skeletal Muscle Myogenic and Atrogenic Gene Expression
Background: Skeletal muscle mass is governed by multiple IGF-1-sensitive positive regulators of muscle-specific protein synthesis (myogenic regulatory factors which includes myoD, myogenin and Myf5)Expand
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Effect of milking interval on milk yield and quality and rate of recovery during subsequent frequent milking
Abstract Forty mid-lactation, pasture-fed dairy cows were used to study the effects of milking interval on milk yield and quality and whether effects could be reversed during a short period ofExpand
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Lack of association between allelic status and myostatin content in lambs with the myostatin g+6723G>A allele.
Lambs with the myostatin (MSTN) g+6723G>A mutation have a greater muscle mass, which is believed to be associated with reduced myostatin protein abundance. This experiment was designed to determineExpand
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