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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
TLDR
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
TLDR
It is estimated that 8,300 independent, mostly common SNPs contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability.
Genome-wide association study identifies five new schizophrenia loci
TLDR
The role of common genetic variation in schizophrenia in a genome-wide association study of substantial size is examined, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia.
Prevalence and correlates of personality disorders in a community sample.
TLDR
The estimated overall prevalence of DSM-IV personality disorders was 9%.
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia.
TLDR
The GSMA produced significant genomewide evidence for linkage on chromosome 2q and suggests that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations.
Practice guideline for the treatment of patients with obsessive-compulsive disorder.
TLDR
The guideline remains substantially correct and current in its recommendations, and some recommendations are now supported by stronger evidence, and more data is available regarding rates of response to some interventions.
Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.
TLDR
A single-nucleotide polymorphism genotyping screen of 64 candidate genes chosen on the basis of previous linkage or of association and/or biological relevance provides further support for shared genetic susceptibility between schizophrenia and bipolar disorders that involve glutamate-signaling pathways.
Population-based study of first onset and chronicity in major depressive disorder.
TLDR
To estimate risk factors for first lifetime onset and parameters of chronicity following the first episode, including duration, recovery, and recurrence, and to search for predictors of each parameter, a population-based cohort study with 23 years of follow-up is conducted.
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