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Optic disc, cup and neuroretinal rim size, configuration and correlations in normal eyes.
TLDR
Four hundred and fifty-seven unselected normal human optic nerve heads of 319 subjects were evaluated by magnification-corrected morphometry of optic disc photographs, finding that the cup was significantly larger in discs with steep "punched-out" cups and neuroretinal rim area was broadest in the inferior optic disc region.
Human optic nerve fiber count and optic disc size.
TLDR
The results may indicate that the optic nerve fiber count, and the anatomic reserve capacity in progressive optic neuropathies, are higher in eyes with large optic discs than in Eyes with small optic nerve heads.
Role of transforming growth factor-beta1 and its latent form binding protein in pseudoexfoliation syndrome.
TLDR
Increased levels of latent and active TGF-beta1 in the aqueous humor of PEX patients, derived from enhanced local synthesis and activation, promote the buildup of the abnormal extracellular elastic material characteristic of P EX syndrome.
Histomorphometry of the human optic nerve.
TLDR
The age-dependent nerve fiber loss, among other factors, may partially explain the decreased visual performance of older subjects and should be considered in progression and "pseudoprogression" of optic nerve diseases like glaucoma.
Expression of cyclooxygenase-1 and -2 in normal and glaucomatous human eyes.
TLDR
Investigation of the expression of the PG-synthesizing enzymes cyclooxygenase (COX)-1 and -2 found specific loss of COX-2 expression in the nonpigmented secretory epithelium of the ciliary body appears to be linked to the occurrence of POAG and steroid-induced glaucoma.
Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder?
TLDR
Findings provide evidence for the systemic nature of the pseudoexfoliation syndrome, which apparently involves an aberrant connective-tissue metabolism throughout the body.
Trabecular meshwork in pseudoexfoliation syndrome with and without open-angle glaucoma. A morphometric, ultrastructural study.
TLDR
Accumulation of locally produced PEX material in the JCT, followed by dysfunction of endothelial cells and disorganization of JCT and Schlemm's canal, appear to be causative factors in the development of a special type of secondary open-angle glaucoma in PEX syndrome.
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