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Guidelines for the Treatment of Acidaemia with THAM
SummaryTHAM (trometamol; tris-hydroxymethyl aminomethane) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. At 37°C, the pK (the pHExpand
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Pharmacokinetics of THC in brain and testis, male gametotoxicity and premature apoptosis of spermatozoa
An earlier report described the pharmacokinetics of delta‐9 THC and the resulting brain function responses. In the present studies the pharmacokinetics of THC in plasma, brain and testis were relatedExpand
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The pharmacokinetics of THC in fat and brain: resulting functional responses to marihuana smoking
  • G. Nahas
  • Chemistry, Medicine
  • Human psychopharmacology
  • 1 April 2001
A pleasant sensory perception (PSP), the high of THC or of marihuana consumption, is a consistent functional response to this drug only manifested by man, and which occurs concurrently with anExpand
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The place of THAM in the management of acidemia in clinical practice
TITRATING agents should only be used to correct acidemia after attempts to correct the underlying causes of this life-threatening condition have failed. This requires optimization of: ventilation CO2Expand
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CYCLIC AMP AND SMOOTH MUSCLE FUNCTION *
In spite of intensive investigation, the nature of the biochemical processes involved in the regulation of smooth muscle tone and contractility is poorly understood.', In the present paper we provideExpand
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Inhibition of catecholamine-induced calorigenesis and lipolysis by hypercapnic acidosis.
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The pharmacology of tris(hydroxymethyl) aminomethane (THAM).
  • G. Nahas
  • Chemistry, Medicine
  • Pharmacological reviews
  • 1 September 1962
THAM is a titrating agent in vivo as well as in vitro , and its ionized fraction acts in the kidney as a non-reabsorbable cation. Since, at normal blood pH, THAM is 70% ionized, the larger part ofExpand
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Effects of cannabinoids on macromolecular synthesis and replication of cultured lymphocytes.
The lymphocyte response to phytohemagglutinin (PHA) as measured by [13H]thymidine incorporation is equally inhibited by 10(-5) to 10(-4) M concentrations of delta8, and delta9-tetrahydrocannabinolExpand
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Use of an Organic Carbon Dioxide Buffer in vivo
  • G. Nahas
  • Chemistry, Medicine
  • Science
  • 20 March 1959
The compound 2-amino-2(hydroxymethyl)1,3-propane diol was administered intravenously to apneically oxygenated dogs over a 1-hour period. Arterial blood pH remained normal, and an estimated 18 to 28Expand
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