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Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1
Neurofibromatosis type I (NF1) is one of the most common single-gene disorders that causes learning deficits in humans. Mice carrying a heterozygous null mutation of the Nf1 gene (Nf1+/−) show… Expand
Neurofibromin Regulation of ERK Signaling Modulates GABA Release and Learning
We uncovered a role for ERK signaling in GABA release, long-term potentiation (LTP), and learning, and show that disruption of this mechanism accounts for the learning deficits in a mouse model for… Expand
Modulation of Presynaptic Plasticity and Learning by the H-ras/Extracellular Signal-Regulated Kinase/Synapsin I Signaling Pathway
- S. Kushner, Y. Elgersma, +11 authors A. Silva
- Biology, Medicine
- The Journal of Neuroscience
- 19 October 2005
Molecular and cellular studies of the mechanisms underlying mammalian learning and memory have focused almost exclusively on postsynaptic function. We now reveal an experience-dependent presynaptic… Expand
Mediation of classical conditioning in Aplysia californica by long-term potentiation of sensorimotor synapses.
Long-term potentiation (LTP) is considered an important neuronal mechanism of learning and memory. Currently, however, there is no direct experimental link between LTP of an identified synapse and… Expand
Compensatory network changes in the dentate gyrus restore long-term potentiation following ablation of neurogenesis in young-adult mice
- B. Singer, Amy E Gamelli, Cynthia L. Fuller, Stephanie J Temme, J. Parent, G. Murphy
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 14 March 2011
It is now well established that neurogenesis in the rodent subgranular zone of the hippocampal dentate gyrus continues throughout adulthood. Neuroblasts born in the dentate subgranular zone migrate… Expand
Deletion of the L‐type calcium channel CaV1.3 but not CaV1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons
- Amy E Gamelli, B. McKinney, Jessica A White, G. Murphy
- Psychology, Medicine
- 1 February 2011
Trains of action potentials in CA1 pyramidal neurons are followed by a prolonged calcium‐dependent postburst afterhyperpolarization (AHP) that serves to limit further firing to a sustained… Expand
The L-Type voltage-gated calcium channel Cav1.3 mediates consolidation, but not extinction, of contextually conditioned fear in mice.
Using pharmacological techniques, it has been demonstrated that both consolidation and extinction of Pavlovian fear conditioning are dependent to some extent upon L-type voltage-gated calcium… Expand
L-type voltage-gated calcium channels in conditioned fear: a genetic and pharmacological analysis.
Using pharmacological approaches, others have suggested that L-type voltage-gated calcium channels (L-VGCCs) mediate both consolidation and extinction of conditioned fear. In the absence of L-VGCC… Expand
Imatinib treatment reduces brain injury in a murine model of traumatic brain injury
Current therapies for Traumatic brain injury (TBI) focus on stabilizing individuals and on preventing further damage from the secondary consequences of TBI. A major complication of TBI is cerebral… Expand
Conditional forebrain deletion of the L-type calcium channel Ca V 1.2 disrupts remote spatial memories in mice.
- Jessica A White, B. McKinney, M. C. John, P. Powers, T. Kamp, G. Murphy
- Psychology, Medicine
- Learning & memory
To determine whether L-type voltage-gated calcium channels (L-VGCCs) are required for remote memory consolidation, we generated conditional knockout mice in which the L-VGCC isoform Ca(V)1.2 was… Expand