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Activation of oxytocin neurones by systemic cholecystokinin is unchanged by morphine dependence or withdrawal excitation in the rat.
Morphine withdrawal excitation of oxytocin neurones does not involve supersensitivity to the noradrenergic input, or hypersensitivity of this input to i.C.V. CCK, and tolerance apparently occurs both at the cell bodies of oxymorphone neurones in the supraoptic nucleus and in their noradRenergic input. Expand
Comparison of the Novel Subtype-Selective GABAA Receptor-Positive Allosteric Modulator NS11394 [3′-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with Diazepam, Zolpidem,
The robust therapeutic window seen with NS11394 in animals suggests that compounds with this in vitro selectivity profile could have potential benefit in clinical treatment of pain in humans. Expand
NS11394 [3′-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a Unique Subtype-Selective GABAA Receptor Positive Allosteric Modulator: In Vitro Actions, Pharmacokinetic
It is shown that NS11394 is potent and highly effective in rodent anxiety models and represents an excellent pharmacological tool to further the authors' understanding on the relative contributions of GABAA receptor subtypes in various therapeutic areas. Expand
Pharmacological comparison of anticonvulsant drugs in animal models of persistent pain and anxiety
The combined antinociceptive and anxiolytic-like profiles of lamotrigine, gabapentin and riluzole suggests that these compounds likely modulate both sensory and affective dimensions of pain. Expand
The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU‐120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat
Allosteric modulation of ligand‐gated receptors is recognized as a potential strategy to obtain desired efficacy in the absence of the putative adverse effects associated with agonist activation. Expand
Kv 7 positive modulators reduce detrusor overactivity and increase bladder capacity in rats.
Results suggest that retigabine and other KV 7 channel positive modulators may have beneficial effects on bladder overactivity partly via activation of Kv 7 channels expressed in bladder tissue. Expand
Positive allosteric modulation of α4β2 nAChR agonist induced behaviour
Results emphasize involvement of α4β2 nAChR in rotational and analgesic responses and confirm striatal α4 β2 receptors to be of the HS form and in vitro experiments were applied to determine dopamine release from striatal minces. Expand
Oxytocin neurone autoexcitation during morphine withdrawal in anaesthetized rats
Central endogenous Oxytocin may be involved in withdrawal excitation of oxytocin neurones in morphine-withdrawal excitation in morphinedependent rats. Expand
Antinociceptive activity of the new triple reuptake inhibitor NS18283 in a mouse model of chemotherapy‐induced neuropathic pain
This study compared the acute antinociceptive effects of NS18283, a novel triple monoamine reuptake inhibitor (MRI) with indatraline, venlafaxine and escitalopram in a mouse model of neuropathic pain. Expand
Dopamine D(1) and D(2) receptor agonism enhances antinociception mediated by the serotonin and noradrenaline reuptake inhibitor duloxetine in the rat formalin test.
  • G. Munro
  • Medicine
  • European journal of pharmacology
  • 2007
Results suggest that antidepressant drugs that can enhance the activity of 5-HT, noradrenaline and dopamine neurotransmission within nociceptive pathways should provide a broader spectrum of antinociception than dual mechanism of action reuptake inhibitors in animal models of injury-induced persistent nocICEption. Expand