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Isolation of a novel species of flavivirus and a new strain of Culex flavivirus (Flaviviridae) from a natural mosquito population in Uganda
The discovery, isolation and characterization of two novel ‘insect-only’ flaviviruses from Entebbe, Uganda: a novel lineage tentatively designated Nakiwogo virus (NAKV) and a new strain of CxFV. Expand
Isolation of a new strain of the flavivirus cell fusing agent virus in a natural mosquito population from Puerto Rico.
Results from viral screening, and cell culture and molecular identification of the infected mosquitoes are presented, supporting previous suggestions of the existence of a large number of unsampled flaviviruses and elucidating the mechanism by which flaviviral sequences may have integrated into mosquito genomes. Expand
Genetic characterization of tick-borne flaviviruses: new insights into evolution, pathogenetic determinants and taxonomy.
Analysis of coding sequences of all recognized tick-borne flavivirus species suggest a complex relationship between viruses infecting birds and those infecting mammals and ticks that feed on both categories of vertebrates may constitute the evolutionary bridge between the three distinct identified lineages. Expand
Structure and functionality in flavivirus NS-proteins: Perspectives for drug design
Structural and functional aspects emerging from the characterization of two main components (NS3 and NS5 proteins) of the flavivirus replication complex are reviewed to shed light on the design and development of antiviral drug leads. Expand
Massilia virus, a novel Phlebovirus (Bunyaviridae) isolated from sandflies in the Mediterranean.
Microscopic, antigenic and genetic analyses indicate that this novel virus belongs to the genus Phlebovirus in the family Bunyaviridae, and is proposed as a member of the Sandfly fever Naples virus complex; its public health importance has yet to be determined. Expand
Concurrent Chikungunya and Dengue Virus Infections during Simultaneous Outbreaks, Gabon, 2007
An outbreak of febrile illness occurred in Gabon in 2007, with 20,000 suspected cases. Chikungunya or dengue-2 virus infections were identified in 321 patients; 8 patients had documentedExpand
Novel Virus Discovery and Genome Reconstruction from Field RNA Samples Reveals Highly Divergent Viruses in Dipteran Hosts
It is clear that viral transmission and maintenance cycles in nature are likely to be significantly more complex and taxonomically diverse than previously expected. Expand
A real-time RT-PCR method for the universal detection and identification of flaviviruses.
An optimized molecular protocol that combines the convenient real-time polymerase chain reaction (PCR) format with a broad spectrum of flavivirus detection and identification, and is a good candidate for the identification of previously identified flaviviruses in cell culture and the investigation of field samples, is described. Expand
Alkhurma Hemorrhagic Fever Virus in Ornithodoros savignyi Ticks
One Ornithodoros savignyi tick from Saudi Arabia contained AHFV RNA, the first direct evidence thatAHFV is a tickborne flavivirus, and confirms the association between human AHfV cases and tickbite history. Expand
Punique virus, a novel phlebovirus, related to sandfly fever Naples virus, isolated from sandflies collected in Tunisia.
Genetic and phylogenetic characterization based on sequences in the three genomic segments showed that it was a novel virus distinct from other recognized members of the species, provisionally named Punique virus. Expand