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Prolongation and enhancement of serum methotrexate concentrations by probenecid.
The disappearance of methotrexate (MTX) from the serum after an intravenous bolus injection and intravenous infusion was studied over 24 hours in eight and four patients respectively. Probenecid… Expand
The clinical phcarmacology of single doses of otilonium bromide in healthy volunteers
AbstractObjective: Otilonium is a smooth muscle spasmolytic with greater affinity for receptors in the smooth muscle of distal than proximal gut in rats. This study was the first to compare distal… Expand
Destruction of chlorpromazine during absorption in the rat in vivo and in vitro
1 Concentrations of total radioactivity in plasma of rats given intravenous and oral 35S‐chlorpromazine, were similar. Concentrations of unchanged drug, however, were lower after oral doses. 2… Expand
Plasma disappearance and cerebral effects of chlorpromazine in cirrhosis.
- J. D. Maxwell, M. Carrella, J. Parkes, R. Williams, G. Mould, S. Curry
- Clinical science
- 1 August 1972
SUMMARY 1. The plasma disappearance and cerebral effects of chlorpromazine were studied in twenty-four patients with compensated cirrhosis and in matched controls using a sensitive gas-liquid… Expand
Radioimmunoassay of Amitriptyline and Nortriptyline in Body Fluids
Summary A radioimmunoassay for the measurement of amitriptyline and nortriptyline in serum, saliva, and urine is described. The sensitivity of the assay is such that 0·5 ng/ml of drug can be… Expand
The interaction between methotrexate and probenecid in man [proceedings].
Comparison of internal reliability and validity of the McGill Pain Questionnaire and the Short Pain Inventory
SummaryWe compared the psychometric properties of the McGill Pain Questionnaire (MPQ) with the 17-item Short Pain Inventory© (SPI) in 60 outpatients with osteoarthritic knee pain. Split-half… Expand
Interference by newer cephalosporins in current methods for measuring creatinine.
Physiologic and clinical effects of chlorpromazine and their relationship to plasma level
- G. Sakalis, S. Curry, G. Mould, M. Lader
- Clinical pharmacology and therapeutics
- 1 November 1972
Ten patients suffering from functional psychoses who had not received medication for one month were studied. After investigation before treatment, they received chlorpromazine in liquid form, 100 mg.… Expand
Gas chromatographic identification of thioridazine in plasma, and a method for routine assay of the drug
Thioridazine had a retention time of approximately 4 min on a 3% OV‐17 gas chromatographic column at 260°. Using flame or argon ionization detectors samples as low as 0μ01 μg could be detected. The… Expand