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Mechanism and regulation of protein degradation in liver.
The degradation of intracellular protein and other cytoplasmic macromolecules in liver is an ongoing process that regulates cytoplasmic mass and provides amino acids for energy and other metabolicExpand
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Quantitative relationship between autophagy and proteolysis during graded amino acid deprivation in perfused rat liver.
Fractional volumes of lysosomal-vacuolar elements and long lived protein degradation were quantitatively correlated in rat livers perfused in the single pass mode with varying levels of plasma aminoExpand
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Intracellular protein catabolism and its control during nutrient deprivation and supply.
The continuous turnover of intracellular protein and other macromolecules is a basic cellular process that serves, among other functions, to regulate cytoplasmic content and provide amino acids forExpand
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Glucagon-induced autophagy and proteolysis in rat liver: mediation by selective deprivation of intracellular amino acids.
Amino acid deprivation and glucagon are both potent inducers of autography and proteolysis in liver. Because glucagon enhanced the metabolic utilization of some amino acids, the catabolic response toExpand
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Requirement for alanine in the amino acid control of deprivation-induced protein degradation in liver.
Protein degradation in liver is actively controlled by a small group of inhibitory amino acids--leucine, tyrosine (or phenylalanine), glutamine, proline, histidine, tryptophan, and methionine. OtherExpand
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Improvement in spermatogenesis following depression of human testis with testosterone.
The short- and long-term effects of testosterone were studied in healthy young adult men. 13 patients were injected with 25 mg/day testosterone propionate for 24-29 days and 7 patients were implantedExpand
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Multifunctional control of amino acids of deprivation-induced proteolysis in liver. Role of leucine.
The control of intracellular proteolysis by amino acids was investigated in rat livers perfused in the single pass mode with various mixtures at multiples of normal plasma concentrations. TwelveExpand
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Quantitative correlation between proteolysis and macro- and microautophagy in mouse hepatocytes during starvation and refeeding.
Cytoplasmic protein in hepatocytes is sequestered and degraded by two general classes of lysosomes, overt autophagic vacuoles (macroautophagy) and dense bodies (microautophagy). Volumes of theExpand
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Regulation of phenylalanine hydroxylase activity by phenylalanine in vivo, in vitro, and in perfused rat liver.
We show that phenylalanine is able to control the extent of activation and, as a result, the catalytic activity of rat liver phenylalanine hydroxylase in vivo, in perfused liver, and in vitro. BothExpand
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Regulation of microautophagy and basal protein turnover in rat liver. Effects of short-term starvation.
Basal rates of long-lived (resident) protein degradation in rat liver, measured during perfusion after amino acid suppression of macroautophagy, were shown to be strongly regulated by caloricExpand
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