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The radiation biology of boron neutron capture therapy.
Experimental studies described in this review constitute the radiobiological basis for the new BNCT clinical trials for glioblastoma at Brookhaven National Laboratory, at the Massachusetts Institute of Technology, and at the High Flux Reactor, Petten, The Netherlands. Expand
Response of rat skin to boron neutron capture therapy with p-boronophenylalanine or borocaptate sodium.
It was concluded on the basis of these calculations that the microdistribution of the two neutron capture agents had a critical bearing on the overall biological effect after thermal neutron activation. Expand
The radiobiological principles of boron neutron capture therapy: a critical review.
The radiobiology of the dose components in a BNCT exposure is examined. The effect of exposure time in determining the biological effectiveness of γ-rays, due to the repair of sublethal damage, hasExpand
Murine EMT-6 Carcinoma: High Therapeutic Efficacy of Microbeam Radiation Therapy
It is suggested that single-fraction microbeams can ablate tumors at high rates with relatively little normal-tissue toxicity. Expand
Response of the central nervous system to boron neutron capture irradiation: evaluation using rat spinal cord model.
The response of the central nervous system to boron neutron capture irradiation, with either p-boronophenylalanine (BPA) or borocaptate sodium (BSH) as neutron capture agents, has been assessed usingExpand
Central nervous system tolerance to boron neutron capture therapy with p-boronophenylalanine.
Simulations using boron neutron capture therapy (BNCT) treatment planning software indicate a significant therapeutic advantage could be obtained in moving to higher BPA doses than those in current clinical use. Expand
Boron Neutron Capture Therapy: Application of Radiobiological Principles
The radiobiological characteristics of the different dose components of BNCT exposure are examined. Dose-rate determines the biological effectiveness of γ-rays, due to the capacity of cells to repairExpand
Response of avian embryonic brain to spatially segmented x-ray microbeams.
Brain tolerance was estimated to be about three times higher to microbeam irradiation as compared with broad beam irradiation, as compared to the broad beam modality. Expand
Late Effects of Radiation on the Central Nervous System: Role of Vascular Endothelial Damage and Glial Stem Cell Survival
The large differences seen in glial progenitor survival seen 1 week after irradiation were also maintained during the 4–5-month latent period before the development of radiation myelopathy, due to selective white matter necrosis, after irradiated with doses that would produce a high incidence of radiationMyelopathy. Expand
Response of Rat Skin to High-Dose Unidirectional X-Ray Microbeams: A Histological Study
The high tolerance of the rats' skin to microbeams and the rapid regeneration of the damaged segments of skin were attributed to the surviving clonogenic cells situated between the adjacent microplanar beams. Expand