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Electrical and mechanical effects of BRL34915 in guinea‐pig isolated trachealis

It is concluded that BRL34915 evokes relaxation of the trachealis by a mechanism that involves neither β‐adrenoceptor activation nor direct reduction of the sensitivity of the intracellular contractile machinery to cytosolic free Ca2+.
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Electrophysiological and other aspects of the relaxant action of isoprenaline in guinea‐pig isolated trachealis

It is concluded that isoprenaline activates β‐adrenoceptors in guinea‐pig trachealis and thereby evokes relaxation and hyperpolarization of the smooth muscle and does not involve the opening of apamin‐sensitive K+‐channels.
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Regional vasorelaxant selectivity of atrial natriuretic factor in isolated rabbit vessels.

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The relaxant action of nicorandil in guinea‐pig isolated trachealis

It is concluded that nicorandil‐induced relaxation does not involve the activation of β‐adrenoceptors but is partly attributable to the formation of nitric oxide from the nitrate moiety in its molecular structure.
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Antihypertensive and cardiac effects of two novel beta-adrenoceptor blocking drugs.

Two new beta-adrenoceptor blocking drugs with acute antihypertensive and positive inotropic effects are described; in SH rats both compounds, given orally, lowered arterial pressure and were more potent than hydralazine.
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Mechanical and electrical aspects of the relaxant action of aminophylline in guinea‐pig isolated trachealis

It is concluded that aminophylline does not directly reduce the sensitivity of the contractile proteins to cytosolic Ca2+ and may involve the opening of K+‐channels which are inhibited by procaine and (to a lesser extent) by TEA.
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Cardiotonic Effects of Anthopleurin‐A, a Polypeptide from a Sea Anemone

The positive inotropic effect of anthopleurin-A (AP-A) was studied in vitro on isolated cat heart papillary muscles and in vivo in anesthetized and conscious dogs, finding that the therapeutic index of AP-A was significantly higher than that of digoxin.
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Responses to Amrinone in Isolated Cardiac Muscles from Cat, Rabbit, and Guinea Pig

The cat papillary muscle was the most sensitive preparation to the inotropic effect of amrinone, and in the rabbit papillary Muscle, β-adrenoceptors contribute to the amrin one response but are not solely responsible for the enhanced inotropy.
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The effect on blood pressure of beta-adrenoceptor blocking drugs administered once daily and their duration of action when therapy is ceased.

The control of blood pressure achieved was similar whether pindolol or propranolol was given once or three times daily and the antihypertensive effect lasted for longer than 24 h when the drugs were ceased.
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Inhibitory responses to nicotine and transmural stimulation in hyoscine‐treated guinea‐pig isolated trachealis: an electrical and mechanical study

It is concluded that nicotine and transmural stimulation can excite intramural noradrenergic nerves in guinea‐pig trachea and thereby evoke Relaxation and membrane potential changes similar to those evoked by the administration of agonists at β‐adrenoceptors.
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