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Antiproliferative Alkaloids from Crinum zeylanicum
Crinum zeylanicum is used in folk medicine as a rubefacient in rheumatism, a treatment for malaria or as a poison. Complex alkaloid profiles in C. zeylanicum plant organs were revealed by GC‐MSExpand
Cytotoxic activity of a podophyllotoxin-like lignan from Linum tauricum Willd.
The present study describes the preliminary evaluation of the cytotoxic activity of a podophyllotoxin-like compound 4'-demethyl-6-methoxypodophyllotoxin (4'-DM-6-Mptox), isolated as one of the mainExpand
Ivermectin as a potential COVID-19 treatment from the pharmacokinetic point of view
The broad-spectrum antiparasitic agent ivermectin has been very recently found to inhibit SARS-CoV-2 in vitro and proposed as a candidate for drug repurposing in COVID-19. In the present report theExpand
Production of podophyllotoxin in Linum linearifolium in vitro cultures
For the first time, callus and suspension cultures of Linum linearifolium were initiated. Podophyllotoxin (PTOX), a strong antitumor precursor, was isolated from the calli and suspension, as a mainExpand
Anticancer Potencies of Pt(II) - and Pd(II)-linked M2L4 Coordination Capsules with Improved Selectivity.
Pt(II) - and Pd(II)-linked M2 L4 coordination capsules, providing a confined cavity encircled by polyaromatic frameworks, exhibit anticancer activities superior to cisplatin against two types ofExpand
Production of justicidin B, a cytotoxic arylnaphthalene lignan from genetically transformed root cultures of Linum leonii.
Callus and hairy root cultures of Linum leonii were established. The genetic transformation in hairy roots was proven by PCR analysis, which showed integration of rol A and rol C genes into the plantExpand
M2L4 coordination capsules with tunable anticancer activity upon guest encapsulation.
Metallosupramolecular cages and capsules have gained increasing popularity as both molecular containers and anticancer agents. For successful combination of these properties a thorough analysis ofExpand
Poly(ethoxytriethyleneglycol acrylate) cryogels as novel sustained drug release systems for oral application
Novel temperature sensitive cryogels of poly(ethoxytriethyleneglycol acrylate) (PETEGA), with in situ entrapped active substance, are synthesized employing the UV irradiation technique and tested asExpand
Effect of justicidin B - a potent cytotoxic and pro-apoptotic arylnaphtalene lignan on human breast cancer-derived cell lines.
Justicidin B produced by genetically transformed cultures of Linum leonii was tested for cytotoxic activity and induction of apoptosis in MDA-MB-231 and MCF-7 breast cancer derived cell lines. TheExpand
Preparation of efficient quercetin delivery system on Zn-modified mesoporous SBA-15 silica carrier.
Mesoporous silica material type SBA-15 was modified with different amounts of Zn (2 and 4wt.%) by incipient wetness impregnation method in ethanol. The parent, Zn-modified and quercetin loadedExpand