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Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle.
Potent sequence selective gene inhibition by siRNA 'targeted' therapeutics promises the ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake, limited blood… Expand
Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation.
Angiogenesis, or the formation of new blood vessels out of pre-existing capillaries, is a sequence of events that is fundamental to many physiologic and pathologic processes such as cancer, ischemic… Expand
Potential cellular and molecular causes of hypertrophic scar formation.
- Willem M van der Veer, M. Bloemen, +4 authors F. Niessen
- Burns : journal of the International Society for…
- 1 February 2009
A scar is an expected result of wound healing. However, in some individuals, and particularly in burn victims, the wound healing processes may lead to a fibrotic hypertrophic scar, which is raised,… Expand
A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo.
To assess the possibilities of retargeting adenovirus to activated endothelial cells, we conjugated bifunctional polyethylene glycol (PEG) onto the adenoviral capsid to inhibit the interaction… Expand
Endothelium in vitro: A review of human vascular endothelial cell lines for blood vessel-related research
Endothelial cells (EC) are currently used as in vitro model systems for various physiological and pathological processes, especially in angiogenesis research. Primary EC have a limited lifespan and… Expand
Albumin modified with mannose 6‐phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells
The hallmark of liver fibrosis is an increased extracellular matrix deposition, caused by an activation of hepatic stellate cells (HSC). Therefore, this cell type is an important target for… Expand
Identification of epigenetically silenced genes in tumor endothelial cells.
Tumor angiogenesis requires intricate regulation of gene expression in endothelial cells. We recently showed that DNA methyltransferase (DNMT) and histone deacetylase (HDAC) inhibitors directly… Expand
Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature
Selective occlusion of tumor vasculature was tested as a therapy for solid tumors in a mouse model. The formation of blood clots (thrombosis) within the tumor vessels was initiated by targeting the… Expand
RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature.
- K. Temming, R. Schiffelers, G. Molema, R. J. Kok
- Medicine, Biology
- Drug resistance updates : reviews and…
- 1 December 2005
During the past decade, RGD-peptides have become a popular tool for the targeting of drugs and imaging agents to alphavbeta3-integrin expressing tumour vasculature. RGD-peptides have been introduced… Expand
Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin.
- R. Schiffelers, G. Koning, +6 authors G. Storm
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 28 August 2003
Angiogenesis is a key process in the growth and metastasis of a tumor. Disrupting this process is considered a promising treatment strategy. Therefore, a drug delivery system specifically aiming at… Expand