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A COMPUTER MODEL OF ATRIAL FIBRILLATION.
The model exhibited self-sustained turbulent activity having many similarities to atrial fibrillation, and suggests the formulation of a “fibrillation” number, similar in concept to the Reynolds number related to turbulence in fluid flow. Expand
Nonuniform Recovery of Excitability in Ventricular Muscle
The degree of dispersion following a basic beat was increased by stimulation of the cardiac sympathetic nerves, administration of chloroform, ouabain intoxication, and administration of higher doses of quinidine, myocardial ischemia, and hypothermia, but it was decreased by administration of sympathomimetic amines. Expand
Atrial fibrillation as a self-sustaining arrhythmia independent of focal discharge.
Physiologic Evidence for a Dual A‐V Transmission System
A study of the transmission of early premature contractions between atria and ventricles and in the retrograde direction in the dog heart suggests the existence of two parallel A-V conduction… Expand
Temporal dispersion of recovery of excitability in atrium and ventricle as a function of heart rate.
It was concluded that spontaneous closely coupled beats occurring at slow ventricular rates in A-V dissociation may result from asynchrony in the repolarization of adjacent excitable units. Expand
Adrenergic Effects on Ventricular Vulnerability
Temporal dispersion of recovery of excitability and the degree of ventricular vulnerability were closely related; the ventricle was more vulnerable to fibrillation when the dispersion was increased. Expand
Effect of Electrotonic Potentials on Pacemaker Activity of Canine Purkinje Fibers in Relation to Parasystole
The results indicate that the discharge pattern of a parasystolic focus may be altered by the electrotonic influence of activity in the surrounding tissue, and this finding is considered in relation to the mechanism of production of parASYstolic rhythms. Expand
Demonstration of a Dual A‐V Nodal Conduction System in the Isolated Rabbit Heart
The intranodal propagation of atrial and ventricular echoes in in-vitro preparations of the rabbit heart was traced from microelectrode records at many puncture sites, and results completely substantiate previous conclusions based on indirect observations in the dog heart. Expand
Aberrant A‐V Impulse Propagation in the Dog Heart: A Study of Functional Bundle Branch Block
Excessive delay and configurational change of ventricular responses to atrial premature beats, previously attributed to dissociation within the A-V node, were shown to be due to functional block of… Expand