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High-Dose, Extended-Interval Colistin Administration in Critically Ill Patients: Is This the Right Dosing Strategy? A Preliminary Study
TLDR
In critically ill patients with otherwise untreatable nosocomial infection due to gram-negative bacteria susceptible only to colistin, a high-dose, extended-interval Colistin dosing regimen is associated with low renal toxicity and high efficacy.
Structure and expression of murine CD30 and its role in cytokine production.
TLDR
It is demonstrated that CD30 directs cytokine secretion and suggest thatCD30 signaling may be pivotal in the pattern of cytokine production by T cells, and the cDNA predicts a protein of 498 amino acids with homology to the TNF receptor family of proteins characterized by repeated cysteine-rich motifs in the extracellular domain.
Chronic endometritis in patients with unexplained infertility: Prevalence and effects of antibiotic treatment on spontaneous conception
TLDR
The correlations between chronic endometritis and unexplained infertility are unexplored and the need for further research is to be addressed.
Rapid and sensitive detection of blaKPC gene in clinical isolates of Klebsiella pneumoniae by a molecular real-time assay
TLDR
In consideration of the serious challenge represented by infections due to K. pneumoniae it appears necessary the rapid identification of carbapenemases in clinical settings as it is made possible by the use of NASBA™ assay.
Human high molecular weight kininogen binds to human umbilical vein endothelial cells via its heavy and light chains.
TLDR
The results indicate that high molecular weight kininogen is capable of binding to endothelial cells via both heavy and light chain moieties, HKa has a higher affinity to HUVEC, and purifiedheavy and light chains are capable of directly binding to H UVEC.
Prevalence of antibodies to Bartonella henselae in patients with suspected cat scratch disease (CSD) in Italy
TLDR
This study shows that the ascertained cases of CSD are etiologically determined by B. henselae, IFA assay is confirmed as a useful tool in the laboratory diagnosis and, over a 5 years period of study, the incidence ofCSD in Italy has been low.
Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia After Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey
TLDR
Pre-engraftment GNB is an independent factor associated with increased mortality rate at 4 months after auto- HSCT and allo-HSCT and a diagnosis of lymphoma, older age, and no antibacterial prophylaxis in auto-HS CT.
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