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Characterization and Recruitment of Plasmacytoid Dendritic Cells in Synovial Fluid and Tissue of Patients with Chronic Inflammatory Arthritis1
Findings suggest that chemokine-driven recruitment of pDCs from the blood to the inflamed synovium could be important in the regulation of the immune response in chronic inflammatory arthritis.
Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability
In RA patients vitamin D deficiency is quite common, but similar to that found in control subjects; disease activity and disability scores are inversely related to 25(OH)D levels.
Patient preferences in the choice of anti-TNF therapies in rheumatoid arthritis. Results from a questionnaire survey (RIVIERA study).
Individual preference seems to be determined by personal attitudes towards safety and convenience, by past experience and by the perception of current disease status in anti-TNF-naive patients.
Two single-nucleotide polymorphisms in the 5' and 3' ends of the osteopontin gene contribute to susceptibility to systemic lupus erythematosus.
These data suggest the independent effect of a promoter (-156) and a 3'-untranslated region (+1239) SNP in SLE susceptibility and can speculate that these sequence variants create a predisposition to high production of OPN, and that this in turn may confer susceptibility to SLE.
Gout impacts on function and health-related quality of life beyond associated risk factors and medical conditions: results from the KING observational study of the Italian Society for Rheumatology
The data from the KING study confirm that gout impacts on disability and provide evidence for an independent association of gout and gout-related features with functional outcome and HRQoL, and supports the need to improve specific treatment in gout.
Effect of low dose methotrexate on bone density in women with rheumatoid arthritis: results from a multicenter cross-sectional study.
No negative effect of low dose MTX on BMD in women with RA is found, and the generalized linear model showed that age, menopause, BMI, HAQ score, and steroid use were significant independent predictors of BMD at lumbar or at femoral level, whereas MTX use was not.
Hypomagnesemia and proton-pump inhibitors
There seems little doubt that PPIs may cause hypomagnesemia, and blood Mg levels should be obtained prior to initiation of PPIs when patients are expected to be on treatment for long period of time and in those with other potential causes.
Italian Society of Rheumatology recommendations for the management of gout.
OBJECTIVE Gout is the most common arthritis in adults. Despite the availability of valid therapeutic options, the management of patients with gout is still suboptimal. The Italian Society of
Italian Society for Rheumatology recommendations for the management of hand osteoarthritis.
The Italian Society for Rheumatology (SIR) aimed to update, adapt to national contest and disseminate the EULAR recommendations for the management of hand OA and developed updated recommendations adapted to the Italian healthcare system.