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Effect of polyunsaturated fatty acids and antioxidants on lipid peroxidation in tissue cultures.
Anti-oxidant effects which were time-dependent showed that intracellular MDA was generated from a lipid peroxide precursor during the thiobarbituric acid assay.
The toxicological evaluation of the mycotoxins T-2 and T-2 tetraol using normal human fibroblasts in vitro.
Normal human fibroblasts in vitro were used as a system to examine the cellular effects of potentially toxic compounds and multiple biochemical parameters with ultrastructural and cytotoxicity studies were effective in demonstrating the mechanisms as well as the degree of toxicity induced by these chemical compounds.
Neoplastic transformation of human diploid cells in vitro after chemical carcinogen treatment
It is reported that primary or low passage cells in vitro from various human foreskin cell populations can be neoplastically transformed in vitro by six different chemical carcinogens.
Transformation of human epithelial cells : molecular and oncogenetic mechanisms
This work presents morphologic and Molecular Characterizations of Plastic Tumor Cell Phenotypes in Culture and Progression from Pigment Cell Patterns to Melanomas in Platyfish-Swordtail Hybrids-Multiple Genetic Changes and a Theme for Tumorsigenesis.
Effects of steroid hormones in fetal bovine serum on plating and cloning of human cells in vitro
Fetal bovine sera from each of three different commercial sources were tested for their ability to support cloning of human fibroblastoid cells in vitro and addition of estrogen or hydrocortisone to a culture medium that inhibits growth, with subsequent reversal of the inhibitory effect, implies that these hormones competitively regulate growth of responsive cells in vivo.
Neoplastic transformation of human epithelial cells in vitro after exposure to chemical carcinogens.
Alatoxin B1, N-methyl-N'-nitro-N-nitrosoguanidine, propanesultone, beta-propiolactone, or ultraviolet absorbance at 254 nm were used successfully as carcinogens.
Inhibition of carcinogen‐induced cellular transformation of human fibroblasts by drugs that interact with the poly(ADP‐ribose) polymerase system
In general, RCF1 was much lower than I 50, and one antitransformer did not inhibit the enzyme in vitro, indicating that low‐affinity enzyme inhibitory sites appear to play no role in the mechanism of prevention of cell transformation.
Physiological concentrations of prolactin can promote the growth of human breast tumor cells in culture.
There is only indirect evidence at present to suggest a role for PRL in either the genesis or progression of human breast cancer. Here, we report the results of experiments in primary cultures of
A comparative study of dimethylhydrazine regioisomers and the methylazoxymethanol metabolite of 1,1- and 1,2-dimethylhydrazine in relation to transformation in human fibroblasts.
The results suggest that other mechanisms may play a role in the initiation of transformation events by hydrazine analogues in human foreskin fibroblasts.
Enhanced expression of the 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase gene in human breast tumor cells.
The elevated expression of 8-oxo-dGTPase in human breast ductal carcinoma cells appears to be a general characteristic of breast tumors and may provide the tumor cell with a cellular defense mechanism to prevent the incorporation of8-hydroxy-deoxyguanosine during DNA replication.