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Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A
Aims Cell therapy trials using cardiac-resident progenitor cells (CPCs) and bone marrow-derived mesenchymal stem/progenitor cells (BMCs) in patients after myocardial infarction have providedExpand
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Hypoxia/Reoxygenation Cardiac Injury and Regeneration in Zebrafish Adult Heart
Aims the adult zebrafish heart regenerates spontaneously after injury and has been used to study the mechanisms of cardiac repair. However, no zebrafish model is available that mimics ischemic injuryExpand
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Myocardial tolerance to ischemia–reperfusion injury, training intensity and cessation
Training has been shown to induce cardioprotection. The mechanisms involved remain still poorly understood. Aims of the study were to examine the relevance of training intensity on myocardialExpand
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Chronic hypoxia: a model for cyanotic congenital heart defects.
OBJECTIVE The postoperative course of cyanotic children is generally more complicated than that of acyanotic children. A possible reason is reoxygenation injury at the beginning of cardiopulmonaryExpand
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A peptide inhibitor of c-Jun NH2-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo.
The c-Jun NH(2)-terminal kinase (JNK) pathway of the mitogen-activated protein kinase (MAPK) signaling cascade regulates cell function and survival after stress stimulation. Equally robust studiesExpand
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Daily reoxygenation decreases myocardial injury and improves post-ischaemic recovery after chronic hypoxia.
OBJECTIVE In contrast to the clinical evidence, experimental studies showed that chronic hypoxia (CH) confers a certain degree of protection against ischaemia-reperfusion damage. We studied theExpand
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Role of Mitogen-Activated Protein Kinases in Myocardial Ischemia-Reperfusion Injury during Heart Transplantation
In solid organ transplantation, ischemia/reperfusion (IR) injury during organ procurement, storage and reperfusion is an unavoidable detrimental event for the graft, as it amplifies graftExpand
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Hypoxia: unique myocardial morphology?
OBJECTIVE The objective of this study was to investigate the effects of chronic and intermittent hypoxia on myocardial morphology. METHODS Rats randomly divided into 3 groups (n = 14 per group)Expand
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Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse.
Myocardial ischaemia-reperfusion (MIR) triggers a sterile inflammatory response important for myocardial healing, but which may also contribute to adverse ventricular remodelling. Such inflammationExpand
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Intravenous administration of cardiac progenitor cell-derived exosomes protects against doxorubicin/trastuzumab-induced cardiac toxicity.
BACKGROUND Combined administration of anthracyclines (e.g., doxorubicin; Dox) and trastuzumab (Trz), a humanized anti-human epidermal growth factor receptor 2 (HER2; ErbB2), is an effective treatmentExpand
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