• Publications
  • Influence
Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients.
TLDR
Although virtually all hMBP peptides tested could be recognized by at least one TCL from MS patients, three immunodominant T cell epitopes were apparent among the TCL examined, corresponding exactly to the hMBp peptides capable of binding to several DR molecules. Expand
Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes
TLDR
Findings suggest that expression of TCR V beta genes, like Ig genes, is developmentally regulated. Expand
Characterization of a novel murine testis-specific serine/threonine kinase.
TLDR
A cDNA fragment encoding a new member of the Ser/Thr (serine/threonine) family of protein kinases is isolated and the name testis-specific kinase-1 (TSK-1) is proposed for the gene described here. Expand
T‐Cell Lineages, Repertoire Selection and Tolerance Induction
TLDR
Data is summarized pertaining to the definition of subsets of immature (CD4-8 ) thymocytes with particular emphasis on their functional activation requirements and TCR expression. Expand
T cell lineages in the thymus of lpr/lpr mice. Evidence for parallel pathways of normal and abnormal T cell development.
TLDR
The results suggest that the massive accumulation of cells in lpr lymph nodes is not so much the result of abnormal proliferation of T cells as abnormal intrathymic differentiation. Expand
Reciprocal expression of myelin-associated glycoprotein splice variants in the adult human peripheral and central nervous systems.
TLDR
Animal experiments may be more representative for the role of MAG in human nerve than in brain, as the deduced amino-acid sequence of the human S-MAG C-terminus shows fairly conservative substitutions compared to the rodent peptide. Expand
Regulation of expression of T cell γ chain, L3T4 and Ly‐2 messages in Abelson/moloney virus‐transformed T cell lines
TLDR
The results indicate that the T cell receptor γ chain genes and those of the cell surface markers CD4 CD8 can be regulated in vitro by external factors and it opens up the possibility of studying the regulatory sequences associated with these genes. Expand
Hepatitis B Virus and HLA Antigen Display in the Liver During Chronic Hepatitis B Virus Infection
TLDR
Differences in the density of HLA and viral antigen display may influence the efficiency of T‐cell cytolysis of hepatitis B virus‐infected hepatocytes. Expand
Abnormal expression of T cell receptor genes in Lyt-2- L3T4- lymphocytes of lpr mice: comparison with normal immature thymocytes.
TLDR
The near normal T cell receptor (TCR)-alpha and -beta mRNA expression by the lpr cells may correspond to an as yet undefined stage ofnormal T cell differentiation. Expand
...
1
2
3
4
5
...