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Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced
Since a dysregulated synthesis of tumor necrosis factor alpha (TNF- alpha) may be involved in the pathogenesis of autoimmune diseases, it was of interest to precisely locate the recently reportedExpand
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NF-kappaB and AP-1 are responsible for inducibility of the IL-6 promoter by ionizing radiation in HeLa cells.
PURPOSE To investigate the mechanisms leading to initiation by ionizing radiation of IL-6 transcription in HeLa cells. MATERIALS AND METHODS HeLa cells were irradiated with X-rays at a dose rate ofExpand
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Structural characteristics of the 5' region of the human ICAM-1 gene.
The ICAM-1 glycoprotein, one of the major cellular adhesion molecules, exhibits a diverse and highly regulated tissue distribution. To better understand the regulatory mechanisms underlying itsExpand
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Clinical and immunologic parameters during thalidomide treatment of lupus erythematosus
Background Thalidomide is used as an experimental drug for the treatment of chronic inflammatory diseases with an autoimmune or infectious background. The pharmacologic action involves theExpand
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Strong and prolonged induction of c-jun and c-fos proto-oncogenes by photodynamic therapy.
Photodynamic therapy (PDT) is currently under investigation in phase II and III clinical studies for the treatment of tumours in superficial localisations. Thus far, the underlying mechanisms of PDTExpand
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Autoantibody Detection Using Indirect Immunofluorescence on HEp‐2 Cells
The detection of autoantibodies is an important element in the diagnosis and monitoring of disease progression in patients with autoimmune diseases. In laboratory diagnostic tests for connectiveExpand
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Cloning and genomic characterization of LST1: a new gene in the human TNF region
The leucocyte specific transcript — 1 (LST1) represents the human homolog of the mouse B144 transcript, encoded within the tumor necrosis factor (TNF) region of the human major histocompatibilityExpand
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Tumor necrosis factor beta (TNF-beta) induces binding of the NF-kappa B transcription factor to a high-affinity kappa B element in the TNF-beta promoter.
The expression of the gene encoding tumor necrosis factor beta (TNF-beta) (lymphotoxin) is induced in T cells by various extracellular stimuli. We noticed that most such stimuli also activate theExpand
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Cicatricial pemphigoid: IgA and IgG autoantibodies target epitopes on both intra‐ and extracellular domains of bullous pemphigoid antigen 180
Background Cicatricial pemphigoid (CP) is an autoimmune subepidermal blistering disease where autoantibodies target various components of the dermal–epidermal junction, including the bullousExpand
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