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Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced
TLDR
Four TNFB alleles can be defined at the DNA level, and putative binding sites conserved between mouse and man in the 5' flanking region as well as in intron 1 of the TNF-beta gene, found also in other cytokine promoter sequences are reported.
NF-kappaB and AP-1 are responsible for inducibility of the IL-6 promoter by ionizing radiation in HeLa cells.
TLDR
The results demonstrate that NF-kappaB plays a major role in X-ray-inducible IL-6 expression in HeLa cells and provide new insights into the prodromal events of radiation-induced inflammation of epithelial cells and putatively the cutaneous radiation syndrome.
Risk factors for lethal outcome in patients with bullous pemphigoid: low serum albumin level, high dosage of glucocorticosteroids, and old age.
TLDR
There is a considerable case-fatality rate in patients with BP and older patients who require a higher dosage of oral glucocorticosteroids at hospital discharge and who have low serum albumin levels are at greater risk of death within the first year after hospitalization.
Autoantibody Detection Using Indirect Immunofluorescence on HEp‐2 Cells
TLDR
In laboratory diagnostic tests for connective tissue and autoimmune liver diseases, indirect immunofluorescence on HEp‐2 cells plays a central role in a multistage diagnostic process.
Clinical and immunologic parameters during thalidomide treatment of lupus erythematosus
TLDR
Not much is known about thalidomide's effect on immunologic parameters in lupus erythematosus (LE), but the pharmacologic action involves the downregulation of the pro‐inflammatory cytokine tumor necrosis factor‐α and inhibition of basic fibroblast growth factor‐induced angiogenesis.
Photodynamic therapy induces expression of interleukin 6 by activation of AP-1 but not NF-kappa B DNA binding.
TLDR
The molecular mechanisms of IL-6 up-regulation upon PDT are analyzed to provide evidence for regulatory differences compared to UV light, ionizing irradiation, or stimulation by phorbol ester, and suggest that the "proinflammatory" cytokine IL- 6 might be involved in the inflammatory reaction and subsequent immunological antitumor responses.
Strong and prolonged induction of c-jun and c-fos proto-oncogenes by photodynamic therapy.
TLDR
This study demonstrates a strong induction of c-jun and c-fos expression by PDT, with prolonged kinetics and mRNA stabilisation as compared with activation by phorbol esters, suggesting that post-translational modifications are dominant regulatory mechanisms after PDT that tightly control AP-1 activity in the nucleus thus limiting the risk of deregulated oncogene expression.
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