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Osteomyelitis: a review of clinical features, therapeutic considerations and unusual aspects.
Osteomyelitis Associated with Vascular Insufficiency The special problems connected with the presentation, clinical course, prognosis and treatment of osteomyelitis associated with vascular insuffi...
Candidemia in a tertiary care hospital: epidemiology, risk factors, and predictors of mortality.
There has been a marked increase in the incidence of candidemia in this institution that is associated with a high overall mortality and Severity of illness and duration of candidemic patients should be used as stratifying factors in prospective studies to determine optimum therapy. Expand
A comparison of amphotericin B alone and combined with flucytosine in the treatment of cryptoccal meningitis.
It is concluded that combined flucytosine-amphoericin B therapy is the regimen of choice in cryptococcal meningitis. Expand
Amphotericin B-induced oxidative damage and killing of Candida albicans.
The lethal and lytic effects of AmB on C. albicans cells and protoplasts, but not prelethal AmB-induced K+ leakage, are mediated by oxidative damage. Expand
Amphotericin B: current understanding of mechanisms of action.
This minireview describes the problems associated with the use of Amphotericin B and what is known about the mechanism(s) of its action. The efforts to design a more efficient vehicle for AmB areExpand
Treatment of cryptococcal meningitis with combination amphotericin B and flucytosine for four as compared with six weeks.
The view is that the four-week regimen should be reserved for patients who have meningitis without neurologic complications, underlying disease, or immunosuppressive therapy; a pretreatment cerebrospinal fluid white-cell count above 20 per cubic millimeter and a serum cryptococcal antigen titer below 1:32. Expand
Amphotericin B-resistant yeast infection in severely immunocompromised patients.
It is concluded that yeast fungemia in severely immunocompromised patients is often caused by organisms resistant to the usual concentrations of amphotericin B obtainable in vivo, and that this finding is clinically significant. Expand
Cutaneous mycobacteriosis: analysis of 34 cases with a new classification of the disease.
A system of classification is proposed which uses simple terms, avoids confusing nomenclature, and incorporates pathophysiologic descriptions and prognostic information to help clinicians understand and diagnose the diverse forms of cutaneous mycobacterial infections. Expand
Strategies in the treatment of systemic fungal infections.
In the past few years, there has been an increase in the number of systemic fungal infections seen in clinical practice, and those due to primary pathogens such as MRSA and Clostridium difficile have been of two types. Expand
Permeabilizing and hemolytic action of large and small polyene antibiotics on human erythrocytes.
In the presence of sucrose, large polyenes were able to inhibit the hemolytic action of small polyenes, implying that both antibiotics have the same binding sites. Expand