G. Mcdonnell

Publications113
h-index31
Citations7,076
Highly Influential Citations363
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Antiseptics and Disinfectants: Activity, Action, and Resistance
TLDR
Known mechanisms of microbial resistance (both intrinsic and acquired) to biocides are reviewed, with emphasis on the clinical implications of these reports. Expand
Mode of action of hydrogen peroxide and other oxidizing agents: differences between liquid and gas forms.
TLDR
These results provide a comprehensive understanding of the differences in interactions between a number of oxidizing agents and macromolecules commonly found in microbial cells, particularly between liquid and gas peroxide. Expand
Free-living amoebae and their intracellular pathogenic microorganisms: risks for water quality.
TLDR
The intention is to provide an informed opinion on the environmental risks associated with the presence of FLA and on the survival of cysts following biocidal treatments, while also highlighting the need to conduct research on the roles of amoebae in aquatic ecosystems. Expand
Novel methods for disinfection of prion-contaminated medical devices
TLDR
New decontamination procedures are proposed to ensure the safety of medical and surgical instruments as well as surfaces that cannot withstand the currently recommended prion inactivation procedures. Expand
Use of hydrogen peroxide as a biocide: new consideration of its mechanisms of biocidal action.
TLDR
This review aims to combine past and novel evidence of interactions between hydrogen peroxide and the microbial cell and its components, while reflecting on alternative applications that make use of gaseous hydrogenperoxide. Expand
Bacterial spore structures and their protective role in biocide resistance
TLDR
This review considers the main spore structures, highlighting their relevance to spore resistance properties and detailing their chemical composition, with a particular emphasis on the differences between various spore formers. Expand
Resistance of Acanthamoeba Cysts to Disinfection Treatments Used in Health Care Settings
TLDR
It is demonstrated that disinfectant efficacy varied depending on the strains tested, with environmental strains demonstrating greater resistance than collection strains, and the need to consider the effective disinfection of protozoa in their vegetative and resistant forms due to their intrinsic resistance is highlighted. Expand
Prion inactivation using a new gaseous hydrogen peroxide sterilisation process.
TLDR
Gaseous peroxide, in addition to known antimicrobial efficacy, was shown to inactivate prions both in in-vitro and in- vivo assays, and may present a useful method for prion inactivation. Expand
Concentration: a major factor in studying biocidal action.
TLDR
Most biocides are formulated for optimal, broad-spectrum antimicrobial activity at high concentrations for direct use on an inanimate or living surface; therefore concentration has obvious practical and clinical implications, as discussed below. Expand
Decontamination with vaporized hydrogen peroxide is effective against Mycobacterium tuberculosis
Aims:  To determine the efficacy of room fumigation with vaporized hydrogen peroxide (VHP) in decontamination of viable Mycobacterium tuberculosis.
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