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Spatial and spectral correlations in MALDI mass spectrometry images by clustering and multivariate analysis.
Matrix-assisted laser desorption/ionization mass spectrometry imaging is a technique for direct analysis of tissue sections without the use of molecular tags or contrast agents. The combination ofExpand
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A matter of fat: an introduction to lipidomic profiling methods.
In recent years, lipidomics or lipid profiling, an extension of metabolomics where the lipid complement of a cell, tissue or organism is measured, has been the recipient of increasing attention as aExpand
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Small-molecule MALDI using the matrix suppression effect to reduce or eliminate matrix background interferences.
The matrix suppression effect (MSE) can lead to high-quality MALDI mass spectra: strong analyte signals and weak or negligible matrix background peaks. Experiment and theory suggest that MSE shouldExpand
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MALDI MS imaging of amyloid.
Label-free molecular imaging by mass spectrometry allows simultaneous mapping of multiple analytes in biological tissue sections. In this chapter, the application of this new technology to theExpand
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Enhanced MALDI ionization efficiency at the metal-matrix interface: Practical and mechanistic consequences of sample thickness and preparation method
Electrosprayed spots of varying thickness were evaluated for use as reproducible, homogenous, high efficiency MALDI samples. Thin samples on stainless steel plates were found to give exceptionallyExpand
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FT-ICR mass spectrometry in the drug discovery process.
The high mass accuracy and resolution of Fourier transform (FT)-ion cyclotron resonance (ICR) mass spectrometry are making it an increasingly useful tool in drug discovery and development. The basicsExpand
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Ion yields of thin MALDI samples: dependence on matrix and metal substrate and implications for models.
Thin MALDI samples can perform differently than thicker samples, on metal substrates. Divergent results and models for the effect have been presented. Positive and negative yields are investigatedExpand
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Mass spectrometric determination of association constants of adenylate kinase with two noncovalent inhibitors
Noncovalent complexes between chicken muscle adenylate kinase and two inhibitors, P1,P4-di(adenosine-5′)tetraphosphate (Ap4A) and P1,P5-di(adenosine-5′) pentaphosphate (Ap5A), were investigated withExpand
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Quantitative evaluation of noncovalent chorismate mutase-inhibitor binding by ESI-MS
Electrospray time-of-flight mass spectrometry was used to quantitatively determine the dissociation constant of chorismate mutase and a transition state analogue inhibitor. This system presents aExpand
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Migration From Food Contact Materials
The transfer of substances from food contact materials to food (migration) constitutes an underestimated source of food contamination. The issue of migration is highlighted by examples of substances,Expand
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