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Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39.
The genome sequences of Chlamydia trachomatis mouse pneumonitis (MoPn) strain Nigg (1 069 412 nt) and Chlamydia pneumoniae strain AR39 (1 229 853 nt) were determined using a random shotgun strategy.Expand
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Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae.
The genome of Chlamydophila caviae (formerly Chlamydia psittaci, GPIC isolate) (1 173 390 nt with a plasmid of 7966 nt) was determined, representing the fourth species with a complete genome sequenceExpand
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Comparative Genomic Analysis of Chlamydia trachomatis Oculotropic and Genitotropic Strains
ABSTRACT Chlamydia trachomatis infection is an important cause of preventable blindness and sexually transmitted disease (STD) in humans. C. trachomatis exists as multiple serovariants that exhibitExpand
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Chlamydial IFN-gamma immune evasion is linked to host infection tropism.
Chlamydiae are obligate intracellular pathogens that can exhibit a broad host range in infection tropism despite maintaining near genomic identity. Here, we have investigated the molecular basis forExpand
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Host cell phospholipids are trafficked to and then modified by Chlamydia trachomatis.
There is little information on the trafficking of eukaryotic lipids from a host cell to either the cytoplasmic membrane of or the vacuolar membrane surrounding intracellular pathogens. PurifiedExpand
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Polymorphisms in Chlamydia trachomatis tryptophan synthase genes differentiate between genital and ocular isolates.
We previously reported that laboratory reference strains of Chlamydia trachomatis differing in infection organotropism correlated with inactivating mutations in the pathogen's tryptophan synthaseExpand
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Chlamydial IFN-γ immune evasion is linked to host infection tropism
Chlamydiae are obligate intracellular pathogens that can exhibit a broad host range in infection tropism despite maintaining near genomic identity. Here, we have investigated the molecular basis forExpand
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Chlamydia trachomatis Plasmid-Encoded Pgp4 Is a Transcriptional Regulator of Virulence-Associated Genes
ABSTRACT Chlamydia trachomatis causes chronic inflammatory diseases of the eye and genital tract and has global medical importance. The chlamydial plasmid plays an important role in theExpand
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The Radical Site in Chlamydial Ribonucleotide Reductase Defines a New R2 Subclass
Ribonucleotide reductase (RNR) synthesizes the deoxyribonucleotides for DNA synthesis. The R2 protein of normal class I ribonucleotide reductases contains a diiron site that produces a stable tyrosylExpand
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Chlamydia trachomatis cytotoxicity associated with complete and partial cytotoxin genes
Chlamydia trachomatis is an obligate intracellular human bacterial pathogen that infects epithelial cells of the eye and genital tract. Infection can result in trachoma, the leading cause ofExpand
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