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Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase‐1 inhibitor GGTI‐298 disrupts MAP kinase activation and G1‐S transition in Ki‐Ras‐overexpressing
TLDR
Combination of two inhibitors, at non‐cytotoxic concentrations, acting on the farnesyl‐pyrophosphate binding site of thefarnesyltransferase and the CaaX binding sites of the geranylgeranyltransferase‐1 respectively is an efficient strategy for disrupting Ki‐Ras tumorigenic cell proliferation. Expand
Long term cell culture of rat liver epithelial cells retaining some hepatic functions.
TLDR
Aldolase showed a specific liver activity with a cleavage ratio of phosphofructoses equal to 1 or about 1 in several primary cultures and cell lines, and various enzymes and metabolic pathways have been studied in primary culture and in cell lines. Expand
Gas chromatography-mass spectrometry of isobutyl ester trimethylsilyl ether derivatives of bile acids and application to the study of bile sterol and bile acid biosynthesis in rat liver epithelial
TLDR
It is demonstrated for the first time that liver epithelial cell lines maintain the metabolic pathway leading from synthesized cholesterol to dioxygenated sterols and the two normal main primary bile acids of the liver, chenodeoxycholic acid and cholic acid, up to 32-47% of the in vivo daily rate. Expand
Biosynthesis of sterols and bile acids in rat liver epithelial cell lines.
TLDR
A rat liver epithelial cell line growing in a serum-supplemented medium expressed biosynthetic pathways of bile sterols and of free and conjugated chenodeoxycholic and cholic acids, the main primary bile acids of the liver, which was demonstrated to sustain cell growth and allow elimination of the interference of exogenous bile steroids and effectors. Expand
A serum-free medium with or without a carrier protein supports the growth of the Y-1 mouse adrenocortical cell line and its steroidogenic function.
TLDR
These studies demonstrate that the use of a defined mixture of nutriments and of few growth factors permits to sustain not only the cellular proliferation of the Y-1 cell line but also its differentiated function of ACTH-induced steroidogenesis. Expand
The serum competitor of oestrogen--rat alpha 1-foetoprotein interactions. Identification as a mixture of non-esterified fatty acids.
TLDR
It is shown that an important fraction of these ligands remains associated with the rat alpha 1-foetop Protein after purification; analyses are given for the composition of this lipid moiety of the foetoprotein. Expand
Role of albumin for the cholesterol transport and on the steroidogenic pathways in serum-free medium newborn rat adrenocortical cell cultures.
TLDR
Internalization of albumin shown by using [methyl-14C]methylated-albumin as a tracer accounted only for a minor part in the cholesterol uptake but strikingly affected the steroidogenic pathways by favoring the reductive metabolism of progesterone over the corticosteroid biosynthesis. Expand
Effect of rat plasma high density lipoprotein with or without apolipoprotein E on the cholesterol uptake and on the induction of the corticosteroid biosynthetic pathway in newborn rat adrenocortical
TLDR
Findings suggest a participation of HDL with apolipoprotein E in the HDL interaction with rat adrenal cells, but the predominant effect on these cells is devoluted to HDL containing mainly apoledipoprotein A. Expand
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