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Skin immunization made possible by cholera toxin
TLDR
It was found that when CT was applied to the surface of the skin, it stimulated an immune response to vaccine components such as diphtheria or tetanus toxoids, and immunization can be achieved by the simple application of a mixture of CT and vaccine components without penetration or disruption of theskin. Expand
Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1.
TLDR
The discovery of a binding specificity of 4E10 for lipid A, a widely used vaccine adjuvant, suggests that innate immunity stimulated by lipid A could have played a role for induction of multispecific antibodies that simultaneously recognize both HIV-1 protein and lipid antigens. Expand
Correlation between Lethal Toxin-Neutralizing Antibody Titers and Protection from Intranasal Challenge with Bacillus anthracis Ames Strain Spores in Mice after Transcutaneous Immunization with
TLDR
Transcutaneous immunization of mice with recombinant protective antigen (rPA) of Bacillus anthracis resulted in significantly higher lethal toxin-neutralizing antibody titers than did intramuscular injection of alum-adsorbed rPA, indicating the significance of protection by this vaccine strategy. Expand
Human Erythrocytes Selectively Bind and Enrich Infectious HIV-1 Virions
TLDR
The results demonstrate that erythrocytes incubated in vitro with HIV-1 differentially adsorb all of the infectious HIV- 1 virions in the absence of complement and independent of blood group, and binding is dependent on divalent cations. Expand
Liposomal adjuvants for human vaccines
TLDR
Liposomes containing monophosphoryl lipid A and QS21 have considerable momentum that will result soon in emergence of prophylactic vaccines to malaria and shingles, and possible novel cancer vaccines. Expand
Subcellular distribution and biosynthesis of rat liver gangliosides.
TLDR
These studies indicate that gangliosides synthesized in the Golgi apparatus may be transported not only to the plasma membrane, but to the endoplasmic reticulum and to other internal endomembranes as well. Expand
Induction of Immune Responses in Mice and Monkeys to Ebola Virus after Immunization with Liposome-Encapsulated Irradiated Ebola Virus: Protection in Mice Requires CD4+ T Cells
TLDR
Mice immunized intravenously with L(EV) were completely protected against illness and death when they were challenged with a uniformly lethal mouse-adapted variant of EBO-Z, indicating a requirement for CD4+ T lymphocytes for successful immunization. Expand
Alteration of glycolipids in ras-transfected NIH 3T3 cells.
TLDR
The results indicated that ras oncogenes derived from human tumors are capable of inducing alterations in glycolipid composition. Expand
Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes
TLDR
The purpose of this initial vaccine study was to produce peptide- and lipid-induced murine mAbs that replicate the characteristics of the 2F5 and/or 4E10 human antibodies in binding both to the membrane proximal external region (MPER) of glycoprotein 41 and the adjacent lipid bilayer for neutralizing HIV-1 infection of CD4+ lymphocytes. Expand
Induction and detection of antibodies to squalene.
TLDR
It is concluded that SQE is a weak antigen, but that antibodies that specifically bind to SQE can be readily induced by immunization with [L(71% SQE+LA)] and detected by ELISA with PVDF membranes coated with SQE. Expand
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