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Identification and characterization of a novel botulinum neurotoxin
Botulinum neurotoxins are known to have seven serotypes (BoNT/A–G). Here we report a new BoNT serotype, tentatively named BoNT/X, which has the lowest sequence identity with other BoNTs and is notExpand
Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides
Angiotensin-I converting enzyme (ACE), a two-domain dipeptidylcarboxypeptidase, is a key regulator of blood pressure as a result of its critical role in the renin-angiotensin-aldosterone andExpand
The structure of the tetanus toxin reveals pH‐mediated domain dynamics
The tetanus neurotoxin (TeNT) is a highly potent toxin produced by Clostridium tetani that inhibits neurotransmission of inhibitory interneurons, causing spastic paralysis in the tetanus disease.Expand
Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme
Angiotensin-I converting enzyme (ACE) is a zinc dipeptidylcarboxypeptidase with two active domains and plays a key role in the regulation of blood pressure and electrolyte homeostasis, making it theExpand
NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
Thiopurines are a standard treatment for childhood leukemia, but like all chemotherapeutics, their use is limited by inherent or acquired resistance in patients. Recently, the nucleoside diphosphateExpand
Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium.
Botulinum neurotoxins (BoNTs), produced by various Clostridium strains, are a family of potent bacterial toxins and potential bioterrorism agents. Here we report that an Enterococcus faecium strainExpand
Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the α2‐adrenoceptors
BACKGROUND AND PURPOSE Muscarinic and adrenergic G protein‐coupled receptors (GPCRs) are the targets of rare peptide toxins isolated from snake or cone snail venoms. We used a screen to identifyExpand
A neurotoxin that specifically targets Anopheles mosquitoes
Clostridial neurotoxins, including tetanus and botulinum neurotoxins, generally target vertebrates. We show here that this family of toxins has a much broader host spectrum, by identifying PMP1, aExpand
Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster
Human somatic angiotensin‐1 converting enzyme (ACE) is a zinc‐dependent exopeptidase, that catalyses the conversion of the decapeptide angiotensin I to the octapeptide angiotensin II, by removing aExpand
Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models
We report the preclinical characterization of two engineered botulinum neurotoxin serotype B proteins with significant therapeutic potential. Although botulinum neurotoxin serotype A (BoNT/A)Expand