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Prevention of intraoperative awareness in a high-risk surgical population.
BACKGROUND Unintended intraoperative awareness, which occurs when general anesthesia is not achieved or maintained, affects up to 1% of patients at high risk for this complication. We tested theExpand
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Perioperative Peripheral Nerve Injuries: A Retrospective Study of 380,680 Cases during a 10-year Period at a Single Institution
Background:Peripheral nerve injuries represent a notable source of anesthetic complications and can be debilitating. The objective of this study was to identify associations with peripheral nerveExpand
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Prevention of Intraoperative Awareness with Explicit Recall in an Unselected Surgical Population: A Randomized Comparative Effectiveness Trial
Background:Intraoperative awareness with explicit recall occurs in approximately 0.15% of all surgical cases. Efficacy trials based on the Bispectral Index® (BIS) monitor (Covidien, Boulder, CO) andExpand
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Conscious Processing and the Global Neuronal Workspace Hypothesis
We review the central tenets and neuroanatomical basis of the global neuronal workspace (GNW) hypothesis, which attempts to account for the main scientific observations regarding the elementaryExpand
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Surge of neurophysiological coherence and connectivity in the dying brain
The brain is assumed to be hypoactive during cardiac arrest. However, the neurophysiological state of the brain immediately following cardiac arrest has not been systematically investigated. In thisExpand
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Disruption of Frontal–Parietal Communication by Ketamine, Propofol, and Sevoflurane
Introduction:Directional connectivity from anterior to posterior brain regions (or “feedback” connectivity) has been shown to be inhibited by propofol and sevoflurane. In this study the authorsExpand
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Perioperative Stroke and Associated Mortality after Noncardiac, Nonneurologic Surgery
Background:Stroke is a leading cause of morbidity and mortality in the United States and occurs in the perioperative period. The authors studied the incidence, predictors, and outcomes ofExpand
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Preferential Inhibition of Frontal-to-Parietal Feedback Connectivity Is a Neurophysiologic Correlate of General Anesthesia in Surgical Patients
Background The precise mechanism and optimal measure of anesthetic-induced unconsciousness has yet to be elucidated. Preferential inhibition of feedback connectivity from frontal to parietal brainExpand
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The directionality and functional organization of frontoparietal connectivity during consciousness and anesthesia in humans
Frontoparietal connectivity has been suggested to be important in conscious processing and its interruption is thought to be one mechanism of general anesthesia. Data in animals demonstrate thatExpand
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Basic FGF and FGF receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: Temporally distinct expression of midkine and pleiotrophen
Heparin‐binding growth factors have been implicated in central nervous system development, regeneration and pathology. To assess the expression pattern and possible function in multiple sclerosis,Expand
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