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Immature Spinal Locomotor Output in Children with Cerebral Palsy
Detailed descriptions of gait impairments have been reported in cerebral palsy (CP), but it is still unclear how maturation of the spinal motoneuron output is affected. Spatiotemporal… Expand
Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain
BackgroundThe CCR2/CCL2 system has been identified as a regulator in the pathogenesis of neuropathy-induced pain. However, CCR2 target validation in analgesia and the mechanism underlying… Expand
1-MCP controls ripening induced by impact injury on apricots by affecting SOD and POX activities
The influence of 1-MCP on the response of apricots to mechanical injury (impact) and the potential involvement of oxidative stress was investigated. Apricots (Prunus armeniaca L. cv. Marietta) picked… Expand
Sex ratio of juvenile loggerhead turtles in the Mediterranean Sea: is it really 1:1?
Sex ratios are a crucial parameter for evaluating population viability. In species with complex life history patterns and temperature sex determination mechanisms, such as the loggerhead turtle… Expand
Discovery of P2X3 selective antagonists for the treatment of chronic pain.
- Louis-David Cantin, M. Bayrakdarian, +14 authors Mirosław J Tomaszewski
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 1 April 2012
Purinergic receptor P2X3 has been linked to analgesia in a number of pre-clinical models of pain, and is expressed in the human pain perception pathway. Only few P2X3-selective antagonists have been… Expand
FLAVONOL GLYCOSIDES FROM ARISTEGUIETIA DISCOLOR AND THEIR INHIBITORY ACTIVITY ON ELECTRICALLY-STIMULATED GUINEA PIG ILEUM
AbstractThe present study reports the isolation of a new flavonol glycoside, 3,5,6,7,8,4′-hexahydroxyflavone-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside (1) along with… Expand
The synthesis of 4 H -pyrrolo[2,1- c ] [1,4] benzoxazine
N-Diphenylmethyl-2-propenamide: theoretical study of the structure and interaction with a DNA model system
Abstract N -diphenylmethyl-2-propenamide (NDP) was synthesised and characterised. Pharmacological in vitro tests pointed out that NDP had a cytotoxic activity on a human ovarian carcinoma comparable… Expand
Antioxidant Activity of Thioureidic Derivatives I.