• Publications
  • Influence
Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.
TLDR
The efficacy of this cDNA cloning strategy was demonstrated by isolating cDNA clones of mRNA from int-2, a mouse gene that expresses four different transcripts at low abundance, the longest of which is approximately 2.9 kilobases.
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.
  • G. Martin
  • Biology
    Proceedings of the National Academy of Sciences…
  • 1 December 1981
TLDR
The establishment directly from normal preimplantation mouse embryos of a cell line that forms teratocarcinomas when injected into mice makes feasible the isolation of pluripotent cells lines from various types of noninbred embryo, including those carrying mutant genes.
The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo.
TLDR
It appears that Fgf8 is structurally the most complex member of the FGF family described to date, with at least seven transcripts encoding a family of secreted FGF8 proteins with different N termini.
An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
TLDR
Analysis of embryos carrying different combinations of these alleles revealed requirements for Fgf8 gene function during gastrulation, as well as cardiac, craniofacial, forebrain, midbrain and cerebellar development.
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
TLDR
It is shown that microRNA-21 regulates the ERK–MAP kinase signalling pathway in cardiac fibroblasts, which has impacts on global cardiac structure and function and confirms miR-21 as a disease target in heart failure and establishes the therapeutic efficacy of microRNA therapeutic intervention in a cardiovascular disease setting.
Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.
TLDR
Evidence is provided that vertebrate Sprouty proteins function as FGF-induced feedback inhibitors, and a possible role is suggested in the pathogenesis of specific human chondrodysplasias caused by activating mutations in Fgfr3.
Functions of FGF signalling from the apical ectodermal ridge in limb development
TLDR
It is shown that FGF4 and FGF8 regulate cell number in the nascent limb bud and are required for survival of cells located far from the AER, and these functions are essential to ensure that sufficient progenitor cells are available to form the normal complement of skeletal elements, and perhaps other limb tissues.
Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.
TLDR
Genetic and biochemical evidence is presented that Pax6 is a key regulator of pancreatic islet hormone gene transcription and is required for normal islet development and that PAX6 transactivates the glucagon and insulin promoters.
Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo.
TLDR
Fgf8 is identified as a gene essential for gastrulation and shows that signaling via FGF8 and/or FGF4 is required for cell migration away from the primitive streak of the gastrulating mouse embryo.
...
...