• Publications
  • Influence
The endogenous cannabinoid system controls extinction of aversive memories
Acquisition and storage of aversive memories is one of the basic principles of central nervous systems throughout the animal kingdom. In the absence of reinforcement, the resulting behaviouralExpand
  • 1,497
  • 125
  • Open Access
CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
Abnormally high spiking activity can damage neurons. Signaling systems to protect neurons from the consequences of abnormal discharge activity have been postulated. We generated conditional mutantExpand
  • 978
  • 69
  • Open Access
Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain
Cannabinoids can modulate motor behaviour, learning and memory, cognition and pain perception. These effects correlate with the expression of the cannabinoid receptor 1 (CB1) and with the presence ofExpand
  • 725
  • 68
The emerging role of the endocannabinoid system in endocrine regulation and energy balance.
During the last few years, the endocannabinoid system has emerged as a highly relevant topic in the scientific community. Many different regulatory actions have been attributed to endocannabinoids,Expand
  • 729
  • 50
  • Open Access
The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus
Balanced control of neuronal activity is central in maintaining function and viability of neuronal circuits. The endocannabinoid system tightly controls neuronal excitability. Here, we show thatExpand
  • 580
  • 38
  • Open Access
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
Although endocannabinoids constitute one of the first lines of defense against pain, the anatomical locus and the precise receptor mechanisms underlying cannabinergic modulation of pain areExpand
  • 449
  • 36
Hardwiring the Brain: Endocannabinoids Shape Neuronal Connectivity
The roles of endocannabinoid signaling during central nervous system development are unknown. We report that CB1 cannabinoid receptors (CB1Rs) are enriched in the axonal growth cones ofExpand
  • 374
  • 31
  • Open Access
Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells
The cannabinoid system is immunomodulatory and has been targeted as a treatment for the central nervous system (CNS) autoimmune disease multiple sclerosis. Using an animal model of multipleExpand
  • 285
  • 29
The endocannabinoid system drives neural progenitor proliferation
The discovery of multipotent neural progenitor (NP) cells has provided strong support for the existence of neurogenesis in the adult brain. However, the signals controlling NP proliferation remainExpand
  • 268
  • 23
  • Open Access
Circuitry for Associative Plasticity in the Amygdala Involves Endocannabinoid Signaling
Endocannabinoids are crucial for the extinction of aversive memories, a process that considerably involves the amygdala. Here, we show that low-frequency stimulation of afferents in the lateralExpand
  • 233
  • 23
  • Open Access