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Characterization of the expression of MHC proteins in human embryonic stem cells
The results demonstrate that human ES cells can express high levels of MHC-I proteins and thus may be rejected on transplantation, and isotyped several of the published ES cell lines for their human leukocyte antigens. Expand
Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus
Human cytomegalovirus, a chief pathogen in immunocompromised people, can persist in a healthy immunocompetent host throughout life without being eliminated by the immune system. Here we show thatExpand
CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cells.
It is demonstrated in vivo that invading EVTs that eventually perform endovascular invasion express CXCL12, the ligand for CXCR4, but not ligands forCXCR3, and that these receptors are involved in migration of all NK subsets to their ligands. Expand
Clinical Responses in a Phase II Study Using Adoptive Transfer of Short-term Cultured Tumor Infiltration Lymphocytes in Metastatic Melanoma Patients
It is shown that lympho-depleting chemotherapy followed by transfer of short-term cultured TIL can mediate tumor regression in 50% of metastatic melanoma with manageable toxicity. Expand
Complexes of HLA-G Protein on the Cell Surface Are Important for Leukocyte Ig-Like Receptor-1 Function1
Immunoprecipitation experiments demonstrated the involvement of the cysteine residues in the formation of HLA-G protein oligomers on the cell surface, which probably bind to Lir-1 with increased avidity, resulting in an enhanced inhibitory function of LIR-1 and an impaired killing function of NK cells. Expand
Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients
Treatment with FMT was associated with favorable changes in immune cell infiltrates and gene expression profiles in both the gut lamina propria and the tumor microenvironment, which have implications for modulating the gut microbiota in cancer treatment. Expand
Recognition of HLA-Cw4 but Not HLA-Cw6 by the NK Cell Receptor Killer Cell Ig-Like Receptor Two-Domain Short Tail Number 41
Enhanced lysis of HLA-Cw4 but not HLA -Cw6-expressing cells, by a subset of NK clones is shown, and Residue α14 is shown to be important in the KIR2DS4 binding to Hla-CW4. Expand
MicroRNA-mediated loss of ADAR1 in metastatic melanoma promotes tumor growth.
It is discovered that ADAR1 fundamentally regulates miRNA processing in an RNA binding–dependent, yet RNA editing–independent manner by regulating Dicer expression at the translational level via let-7 and that aberrant hypomethylation of the imprinted DLK1-DIO3 region in chromosome 14 can also drive miR-432 overexpression. Expand
Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma: Intent-to-Treat Analysis and Efficacy after Failure to Prior Immunotherapies
Adoptive transfer of TIL can yield durable and complete responses in patients with refractory melanoma, even when other immunotherapies have failed. Expand
Triage and management of pericardial effusion
Pericardial effusion may be detected as an incidental finding during echocardiography or following a diagnostic imaging study for a symptomatic patient, and the presence of elevated inflammatory markers and other criteria suggest pericarditis and management should be directed accordingly. Expand