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dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila.
TLDR
The results suggest that posterior margin cells are distinct from other cells of the eye imaginal disc by early stages of development, which is also necessary for proper differentiation of a subset of segments in the developing leg. Expand
Dachshund and Eyes Absent Proteins Form a Complex and Function Synergistically to Induce Ectopic Eye Development in Drosophila
TLDR
It is proposed that a conserved regulatory network, rather than a linear hierarchy, controls retinal specification and involves multiple protein complexes that function during distinct steps of eye development. Expand
Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation.
TLDR
A new layer of regulation is revealed in the process of myogenic specification in the somites of Drosophila, and it is shown that the Pax, Dach, Eya, and Six genetic network has been conserved across species. Expand
The sex-determining region of the human Y chromosome encodes a finger protein
TLDR
The possibility that the Y-encoded finger protein is the testis-determining factor is discussed, and models of sex determination accommodating the finding of a related locus on the X chromosome are proposed. Expand
Ectopic eye development in Drosophila induced by directed dachshund expression.
TLDR
It is shown that dachshund and eyeless induce the expression of each other and that dACHshund is required for ectopic retinal development driven by eyeless misexpression, suggesting that the control of eye development requires the complex interaction of multiple genes, even at the very highest regulatory levels. Expand
Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress
TLDR
Parkin mutants will be a valuable model for future analysis of the mechanisms of cell and tissue degeneration and demonstrate the importance of parkin in maintaining specific cell groups, perhaps those with a high-energy demand and the concomitant production of high levels of free radicals. Expand
A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase
TLDR
The results suggest that Gap1 acts as a negative regulator of signaling by Sevenless by down-regulating the activity of the Ras1 protein, which has been shown to be a key element in signaling by sevenless. Expand
Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless.
TLDR
The results suggest that the integrated strategy of computational biology, genomics, and genetics is a powerful approach to identify direct downstream targets for any transcription factor genome-wide. Expand
Signaling by the TGF-beta homolog decapentaplegic functions reiteratively within the network of genes controlling retinal cell fate determination in Drosophila.
TLDR
It is demonstrated that, during eye development, while eyeless transcription does not depend on decapentaplegic activity, the expression of eyes absent, sine oculis and dachshund are greatly reduced in a decapentablegic mutant background. Expand
R8 development in the Drosophila eye: a paradigm for neural selection and differentiation.
TLDR
The developmental control of the four key elements of R8 development: selection, spacing, differentiation and orchestration of later events are discussed. Expand
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