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Flavonoids from Praxelis clematidea R.M. King and Robinson Modulate Bacterial Drug Resistance
TLDR
The flavones tested did not show any significant antibacterial activity against the Staphylococcus aureus strain used, but were able to modulate bacterial drug resistance, which might be related to the degree of lipophilicity of the flavones conferred by the methoxyl groups.
Lupeol, a Pentacyclic Triterpene, Promotes Migration, Wound Closure, and Contractile Effect In Vitro: Possible Involvement of PI3K/Akt and p38/ERK/MAPK Pathways
TLDR
In keratinocytes, lupeol treatment resulted in the activation of Akt, p38, and Tie-2, which are signaling proteins involved in cell proliferation and migration, angiogenesis, and tissue repair, and these findings suggest thatlupeol has therapeutic potential for accelerating wound healing.
Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice
TLDR
The results indicate that betulinic acid and its derivative compounds are candidates for the development of new antimalarial drugs.
In vitro anti-Candida activity and mechanism of action of the flavonoid isolated from Praxelis clematidea against Candida albicans species -
TLDR
The flavonoid showed in vitro antifungal potential against strains of C. albicans, and involvement with the cell wall and ergosterol binding were comproved as possible mechanisms of action.
Evaluation of naphthoquinones identified the acetylated isolapachol as a potent and selective antiplasmodium agent
TLDR
A semi-synthetic antimalarial naphthoquinone closely related to isolapachol, which had stronger antimalaria activity than lapachol was identified, which did not affect either mitochondria structure or cause DNA fragmentation in parasite treated cells.
Ecdysteroids from Vitex Species: Distribution and Compilation of Their 13C‐NMR Spectral Data
TLDR
This study attempted to summarize previous research on ecdysteroids distribution in Vitex species with the addition of 13C‐NMR analysis to further refine the characterization of these compounds in the Verbenaceae family.
Antifungal Effect of Flavonoid 5, 7, 4'- Trimethoxyflavone against Candida krusei Strains
TLDR
The obtained results showed activity fungistatic against Candida krusei strains and the results were also compared with the standard drug, Nistatin (100 UI/mL).
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