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Epicatechin, catechin, and dimeric procyanidins inhibit PMA‐induced NF‐κB activation at multiple steps in Jurkat T cells
The capacity of the flavan‐3‐ols [(–)‐epicatechin (EC) and (+)‐catechin (CT)] and a B dimeric procyanidin (DP‐B) to modulate phorbol 12‐myristate 13‐acetate (PMA)‐induced NF‐κB activation in Jurkat TExpand
Zinc, oxidant-triggered cell signaling, and human health.
Zinc (Zn) deficiency, a frequent condition in human populations, induces oxidative stress and subsequently activates/inhibits oxidant-sensitive transcription factors that can affect cell function,Expand
Targeting Mitochondrial STAT3 with the Novel Phospho-Valproic Acid (MDC-1112) Inhibits Pancreatic Cancer Growth in Mice
New agents are needed to treat pancreatic cancer, one of the most lethal human malignancies. We synthesized phospho-valproic acid, a novel valproic acid derivative, (P-V; MDC-1112) and evaluated itsExpand
Curcumin induces cell‐arrest and apoptosis in association with the inhibition of constitutively active NF‐κB and STAT3 pathways in Hodgkin's lymphoma cells
Although treatment of Hodgkin's lymphoma (HL) with a multi‐drug approach has been very successful, its toxicity becomes evident after several years as secondary malignancies and cardiovascularExpand
Microtubules are required for NF‐κB nuclear translocation in neuroblastoma IMR‐32 cells: modulation by zinc
The relevance of a functional cytoskeleton for Nuclear Factor‐κB (NF‐κB) nuclear translocation was investigated in neuronal cells, using conditions that led to a disruption of the cytoskeletonExpand
Suppressing glucose metabolism with epigallocatechin-3-gallate (EGCG) reduces breast cancer cell growth in preclinical models.
Numerous studies propose that epigallocatechin-3-gallate (EGCG), an abundant polyphenol in green tea, has anti-cancer properties. However, its mechanism of action in breast cancer remains unclear.Expand
Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations.
Due to long-term toxicity of current Hodgkin's lymphoma (HL) treatment, the present challenge is to find new therapies that specifically target deregulated signaling cascades, including NF-kappaB,Expand
Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds.
Nonsteroidal anti-inflammatory drugs (NSAID) exhibit antineoplastic properties, but conventional NSAIDs do not fully meet safety and efficacy criteria for use as anticancer agents. In this study, weExpand
The Role of Zinc in the Modulation of Neuronal Proliferation and Apoptosis
Although a requirement of zinc (Zn) for normal brain development is well documented, the extent to which Zn can modulate neuronal proliferation and apoptosis is not clear. Thus, we investigated theExpand
Curcumin formulated in solid lipid nanoparticles has enhanced efficacy in Hodgkin's lymphoma in mice.
Curcumin reduces Hodgkin's lymphoma (HL) cell growth in vitro, but its unfavorable pharmacokinetics highlight the need for novel in vivo delivery systems. Thus, we explored whether formulation ofExpand