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Anticonvulsant activity of hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu.
The anticonvulsant effects of hydroalcoholic extracts (HAEs) from the stem bark of Erythrina velutina and Erythrina mulungu on pentylenetetrazole (PTZ) and strychnine-induced seizure tests and theExpand
Adenosine A2A Receptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by β-Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway
Alzheimer's disease (AD) is characterized by memory impairment, neurochemically by accumulation of β-amyloid peptide (namely Aβ1-42) and morphologically by an initial loss of nerve terminals.Expand
Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress
Stress initially causes adaptive changes in the brain and can lead to neurodegeneration if continuously present. Noxious brain conditions trigger the release of adenosine that can control brainExpand
The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdorffii oleo-resin.
In this work, we studied the effects of kaurenoic acid, a diterpene isolated from the oleo-resin of Copaifera langsdorffii in developing sea urchin (Lytechinus variegatus) embryos, on tumor cellExpand
Adenosine A2A receptor blockade prevents memory dysfunction caused by β-amyloid peptides but not by scopolamine or MK-801
Adenosine A2A receptor antagonists alleviate memory deficits caused by aging or by administration of beta-amyloid peptides in rodents, which is in accordance with the beneficial effects of caffeineExpand
Neuroprotective effects of caffeine in the model of 6-hydroxydopamine lesion in rats
The work shows the effects of caffeine after the intrastriatal injection of 6-OHDA in rats, considered as a model of Parkinson disease (PD). Two weeks after the 6-OHDA lesion, rats exhibit aExpand
Antinoceptive effect of triterpenoid alpha,beta-amyrin in rats on orofacial pain induced by formalin and capsaicin.
The effects of alpha,beta-amyrin, a pentacyclic triterpene isolated from Protium heptaphylum was investigated on rat model of orofacial pain induced by formalin or capsaicin. Rats were pretreatedExpand
Antiproliferative Effects of Several Compounds Isolated from Amburana cearensis A. C. Smith
Abstract Amburana cearensis a common tree found in Northeastern Brazil is widely used in folk medicine. The present work evaluated the cytotoxicity of kaempferol, isokaempferide, amburoside A andExpand
Melatonin improves sleep and reduces nitrite in the exhaled breath condensate in cystic fibrosis – a randomized, double‐blind placebo‐controlled study
Abstract:  Cystic fibrosis (CF) is a chronic progressive disorder characterized by repeated episodes of respiratory infection. Impaired sleep is common in CF leading to reduced quality of life.Expand
Antibacterial activity of essential oils from Psidium and Pilocarpus species of plants
The antibacterial activity of six essential oils obtained from the leaves of Pilocarpus and Psidium species of plants have been studied. The leaf oils of Psidium guyanensis, Psidium pohlianum andExpand