The Anti-inflammatory Sesquiterpene Lactone Helenalin Inhibits the Transcription Factor NF-κB by Directly Targeting p65*
- G. Lyss, A. Knorre, T. Schmidt, H. Pahl, I. Merfort
- Biology, ChemistryJournal of Biological Chemistry
- 11 December 1998
This sesquiterpene lactone helenalin is the first anti-inflammatory agent shown to exert its effect by directly modifying NF-κB, the central mediator of the human immune response.
Helenalin, an Anti-Inflammatory Sesquiterpene Lactone from Arnica, Selectively Inhibits Transcription Factor NF-κB
- G. Lyss, T. Schmidt, I. Merfort, H. Pahl
- Biology, ChemistryBiological chemistry
- 1 September 1997
Helenalin inhibits NF-kappaB activation in response to four different stimuli in T-cells, B-cells and epithelial cells and abrogates kappaB-driven gene expression, suggesting a molecular mechanism for the anti- inflammatory effect of sesquiterpene lactones, which differs from that of other nonsteroidal anti-inflammatory drugs (NSAIDs), indomethacin and acetyl salicylic acid.
Helenanolide type sesquiterpene lactones. Part 5: the role of glutathione addition under physiological conditions.
- T. Schmidt, G. Lyss, H. Pahl, I. Merfort
- Chemistry, BiologyBioorganic & Medicinal Chemistry
- 1 December 1999
Study of three sesquiterpene lactones from Tithonia diversifolia on their anti-inflammatory activity using the transcription factor NF-kappa B and enzymes of the arachidonic acid pathway as targets.
- P. Rüngeler, G. Lyss, V. Castro, G. Mora, H. Pahl, I. Merfort
- BiologyPlanta Medica
- 1 October 1998
It is shown that the main sesquiterpene lactones of this species growing in Costa Rica do not influence the enzymes of the arachidonic acid pathway, but inhibit the activation of NF-kappa B.