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Approaches to pseudopeptidic ergopeptines. Synthesis and molecular structure of an α-aza-phenylalanine-containing oxa-cyclol
A synthesis of the tetrahedral adduct (oxa-cyclol)6 structurally related to the peptide portion of ergotamine and possessing an α-aza-phenylalanine residue in place of the central phenylalanine isExpand
Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides
The results showed that the dipeptides efficiently protect tyrosine against nitration, α1-antiproteinase against inactivation and human low-density lipoprotein against modification by peroxynitrite. Expand
Chemotactic peptides: fMLF-OMe analogues incorporating proline-methionine chimeras as N-terminal residue.
The new fMLF analogues 1-4, incorporating chimeric S-proline-methionine residues, have been prepared and their solution conformation and activity as agonists or antagonists of formylpeptide receptors have been studied. Expand
Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2.
A series of novel EM2 and morphiceptin analogues containing in place of the proline at position 2 the S and R residues of beta-homologues of proline and 2-pyrrolidinemethanesulphonic acid have been synthesized and their binding affinity and functional activity have been investigated. Expand
Hybrid α/β-peptides: For-Met-Leu-Phe-OMe analogues containing geminally disubstituted β2,2- and β3,3-amino acids at the central position
Summary.The two fMLF-OMe analogues For-Met-β3hAc6c-Phe-OMe (6) and For-Met-β2hAc6c-Phe-OMe (12) and their corresponding N-Boc derivatives 5 and 11 have been synthesized and their biological activityExpand
Peptide backbone folding induced by the C(alpha)-tetrasubstituted cyclic alpha-amino acids 4-amino-1,2-dithiolane-4-carboxylic acid (Adt) and 1-aminocyclopentane-1-carboxylic acid (Ac5c). A joint
Experimental conformational studies of a new group of synthetic peptides containing 4-amino-1,2-dithiolane-4-carboxylic acid and N-Boc protected tripeptides clearly indicate the remarkable tendency of both the five-membered C(alpha)-tetrasubstituted cyclic amino acids Adt to induce the gamma-turn structure also in models able to adopt the beta-bend conformation. Expand
Hybrid alpha/beta-peptides: for-Met-Leu-Phe-OMe analogues containing geminally disubstituted beta2,2- and beta 3,3-amino acids at the central position.
The two fMLF-OMe analogues For-Met-beta(3)hAc(6)c-Phe- OMe and their corresponding N-Boc derivatives 5 and 11 have been synthesized and their biological activity towards human neutrophils evaluated and the preferred solution conformation of the two N-formyl derivatives has been discussed. Expand
Synthesis and activity of the glutathione analogue gamma-(L-gamma-azaglutamyl)-L-cysteinyl-glycine.
The results indicate that gamma-azapeptides of type 7 may represent interesting targets in the search for stable inhibitors of gamma-glutamyltransferases. Expand
Cyclols, cyclodepsipeptides, and N-acyl-diketopiperazines from linear precursors. Synthesis and crystal structure of 10-membered cyclodepsipeptides.
Two linear peptide precursors containing proline as C-terminal residue, have been synthesized and subjected to cyclizing conditions to investigate the relative formation tendency of different tautomeric ring systems. Expand