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The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism
TLDR
It is found that CARKL-dependent metabolic reprogramming is required for proper M1- and M2-like macrophage polarization and a rate-limiting requirement for appropriate glucose flux in macrophages polarization is uncovered. Expand
The effect of repeated ozone exposures on inflammatory markers in bronchoalveolar lavage fluid and mucosal biopsies.
TLDR
It is demonstrated that airway inflammation persists after repeated ozone exposure, despite attenuation of some inflammatory markers in BALF and adaptation of lung function. Expand
Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders
TLDR
The present data indicate that differential regulation of antioxidant enzymes exist in DS, AD and PD, suggestive of the diversity as well as distinct functional roles of these proteins. Expand
Documenting the diet in ancient human populations through stable isotope analysis of hair.
TLDR
It is suggested that a commonly overlooked material, human hair, may represent an ideal material to be used in addressing human diets of ancient civilizations, and isotopically characterized modern individuals for whom the diet has been documented. Expand
Zinc deficiency induces enhanced depression-like behaviour and altered limbic activation reversed by antidepressant treatment in mice
TLDR
Data support the link between low Zn levels and depression-like behaviour and suggest experimentally-induced Zn deficiency as a putative model of depression in mice. Expand
On the Origin of Extracellular Glutamate Levels Monitored in the Basal Ganglia of the Rat by In Vivo Microdialysis
TLDR
It is concluded that there is a pool of releasable Glu and Asp in the rat brain, and extracellular levels of amino acids monitored by in vivo microdialysis reflect the balance between neuronal release and reuptake into surrounding nerve terminals and glial elements. Expand
Aberrant expression of cytoskeleton proteins in hippocampus from patients with mesial temporal lobe epilepsy
TLDR
The findings may represent or lead to cytoskeletal impairment; aberrant antioxidant proteins, chaperons, MAP kinase kinase 1 and NAD-dependent deacetylase sirtuin-2 may have been involved in pathogenetic mechanisms and altered synaptosomal protein expression possibly reflects synaptic impairment in MTLE. Expand
Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down syndrome and Alzheimer's disease brain is downregulated at the mRNA and dysregulated at the protein level.
TLDR
The decrease of mRNA DRP-2 steady state levels in DS along with deteriorated protein expression of this repulsive guidance molecule of the semaphorin/collapsin family, may help to explain deranged migration and histogenesis of DS brain and wiring of AD brain. Expand
Changes of voltage‐dependent anion‐selective channel proteins VDAC1 and VDAC2 brain levels in patients with Alzheimer's disease and Down Syndrome
TLDR
The biological meaning of the results may be derangement of voltage‐dependent anion‐selective channel function and reflecting impaired glucose, energy, and intermediary metabolism as well as apoptotic mechanisms. Expand
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