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Guidelines for diagnosis and therapy of MEN type 1 and type 2.
TLDR
The specific RET codon mutation correlates with the MEN2 syndromic variant, the age of onset of M TC, and the aggressiveness of MTC; consequently, that mutation should guide major management decisions, such as whether and when to perform thyroidectomy. Expand
Systemic complications of acromegaly: epidemiology, pathogenesis, and management.
TLDR
The most important cause of morbidity and functional disability of this disease is arthropathy, which can be reversed at an initial stage, but not if the disease is left untreated for several years. Expand
Advances in the treatment of prolactinomas.
TLDR
A critical analysis of the efficacy and safety of the various modes of therapy available for the treatment of patients with prolactinomas with an emphasis on challenging situations is provided, a discussion of the data regarding withdrawal of medical therapy, and a foreshadowing of novel approaches to therapy that may become available in the future. Expand
Residual pituitary function after brain injury-induced hypopituitarism: a prospective 12-month study.
TLDR
There is high risk for H in TBI and SAH patients and early diagnosis of PH is always confirmed in the long term, whereas MH and IH were confirmed in 25% only. Expand
Subclinical Cushing's syndrome in patients with adrenal incidentaloma: clinical and biochemical features.
TLDR
An unexpectedly high prevalence of subtle autonomous cortisol secretion, associated with high occurrence of hypertension, diabetes mellitus, elevated lipids, and diffuse obesity, was found in incidentally discovered adrenal adenomas, and supports the hypothesis that clinically silent hypercortisolism is probably not completely asymptomatic. Expand
Effects of thyroid hormone on the cardiovascular system.
TLDR
Preliminary clinical investigations suggest that administration of thyroid hormone or its analogue 3,5-diiodothyropropionic acid greatly benefits these patients, highlighting the potential role of thyroid hormones treatment in patients with acute and chronic cardiovascular disease. Expand
Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure.
TLDR
In conclusion, patients with Cushing's disease still have increased cardiovascular risk and suffer from premature atherosclerosis once cured, and patients was probably due to residual abdominal a long term period of WHR, which was inversely correlated to the duration of CD. Expand
Growth hormone and the heart
TLDR
Several lines of evidence have suggested that the cardiovascular abnormalities can be partially reversed by suppressing GH and IGF‐I levels in acromegaly or after GH replacement therapy in GHD patients. Expand
Patients with subclinical Cushing's syndrome due to adrenal adenoma have increased cardiovascular risk.
TLDR
The results strongly suggest that an increased cardiovascular risk profile, similar to that described in overt Cushing's syndrome, is present in SCS subjects, and supports the concept that chronic mild endogenous cortisol excess may have important systemic effects on the human body. Expand
The medical treatment of Cushing's disease: effectiveness of chronic treatment with the dopamine agonist cabergoline in patients unsuccessfully treated by surgery.
TLDR
It is demonstrated that cabergoline treatment is effective in controlling cortisol secretion for at least 1-2 yr in more than one third of a limited population of patients with CD. Expand
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