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Rho kinases in cardiovascular physiology and pathophysiology.
TLDR
This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of ROCK signaling and its roles in cardiovascular physiology and pathophysiology. Expand
Cyclic GMP-dependent Protein Kinase Signaling Pathway Inhibits RhoA-induced Ca2+ Sensitization of Contraction in Vascular Smooth Muscle*
TLDR
Results indicate that cGK phosphorylates and inhibits RhoA and suggest that the consequent inhibition of RHoA-induced Ca2+ sensitization and actin cytoskeleton organization contributes to the vasodilator action of nitric oxide. Expand
The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure
TLDR
Evidence is provided that Arhgef1 is the RhoA guanine exchange factor specifically responsible for angiotensin II–induced activation of RHoA signaling in arterial smooth muscle cells and identifies Arh gef1 as a potential target for the treatment of hypertension. Expand
Human Urotensin II–Induced Contraction and Arterial Smooth Muscle Cell Proliferation Are Mediated by RhoA and Rho-Kinase
TLDR
It is demonstrated that hU-II induced arterial smooth muscle contraction, actin stress fiber formation, and proliferation through the activation of the small GTPase RhoA and its downstream effector Rho-kinase. Expand
RhoA Expression Is Controlled by Nitric Oxide through cGMP-dependent Protein Kinase Activation*
TLDR
In vitro and in vivo results show that NO/PKG signaling positively controls RhoA expression and suggest that the basal release of NO is necessary to maintain RhoB expression and RHoA-dependent functions in vascular smooth muscle cells. Expand
Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis.
TLDR
This study provides the first evidence that Rho kinase activates I-kappa B kinase and, thus, nuclear factor kappa B, suggesting a key role of Rho Kinase in inflammatory responses and intestinal inflammation. Expand
Shear Stress Regulates Endothelial Microparticle Release
TLDR
It is demonstrated that sustained atheroprone low SS stimulates EMP release through activation of Rho kinases and ERK1/2 pathways, whereas atheroprotective high SS limits EMP release in a NO-dependent regulation of ABCA1 expression and of cytoskeletal reorganization. Expand
Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension
TLDR
It is proposed that sildenafil inhibits RhoA/Rho kinase‐dependent functions in pulmonary artery through enhanced RHoA phosphorylation and cytosolic sequestration by GDI. Expand
Transglutaminase-dependent RhoA Activation and Depletion by Serotonin in Vascular Smooth Muscle Cells*
TLDR
Evidence is provided that 5-HT, internalized through the 5- HT transporter, is transamidated to RhoA by transglutaminase, which in turn is responsible for Akt activation and contraction inhibition in arterial smooth muscle. Expand
Urotensin II is a New Chemotactic Factor for UT Receptor-Expressing Monocytes1
TLDR
U-II is identified as a chemoattractant for UT receptor-expressing monocytes and indicate a pivotal role of the RhoA-Rho kinase signaling cascade in the chemotaxis induced by U-II. Expand
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