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Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013
View on Elsevier
Incidence of amyotrophic lateral sclerosis in Europe
TLDR
Sex differences in incidence may be explained by the higher incidence of spinal onset ALS among men, and the age related disease pattern suggests that ALS occurs within a susceptible group within the population rather than being a disease of ageing.
View on BMJ
Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature
TLDR
Disparity in rates among ALS incidence and prevalence studies may be due to differences in study design or true variations in population demographics such as age and geography, including environmental factors and genetic predisposition.
View on PubMed
Prognostic factors in ALS: A critical review
TLDR
A systematic review of factors related to survival in ALS revealed the rate of symptom progression was revealed to be an independent prognostic factor, and these findings have relevant implications for the design of future trials.
View on Taylor & Francis
Prevalence of depression in chronic kidney disease: systematic review and meta-analysis of observational studies.
TLDR
A systematic review and meta-analysis of observational studies to summarize the point prevalence of depressive symptoms in adults with CKD suggested that self-report scales may overestimate the presence of depression, particularly in the dialysis setting.
View on PubMed
Amyotrophic lateral sclerosis
TLDR
Two possible disease-modifying therapies that can slow disease progression are available for ALS, but patient management is largely mediated by symptomatic therapies, such as the use of muscle relaxants for spasticity and speech therapy for dysarthria.
View on Nature
Incidence and lifetime risk of motor neuron disease in the United Kingdom: a population‐based study
TLDR
To estimate the incidence and lifetime risk of motor neuron disease (MND) in a population‐based sample in the United Kingdom, a population-based sample of 120,000 adults was used.
View on Wiley
A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease
TLDR
Aducanumab, a potent monoclonal antibody specifically directed against Aβ oligomers, produced encouraging preliminary results in patients with prodromal or mild AD, suggesting that oligomeric Aβ species may represent a valid biological target.
View on Springer
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
TLDR
Evidence of ALS being a complex genetic trait with a polygenic architecture is established and the SNP-based heritability is estimated at 8.5%, with a distinct and important role for low-frequency variants (frequency 1–10%).
View on Nature
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene
View on Elsevier
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