• Publications
  • Influence
Protection Against Infarction Afforded by Preconditioning is Mediated by A1 Adenosine Receptors in Rabbit Heart
TLDR
Adenosine released during the preconditioning occlusion stimulates cardiac A 1 receptors, which leaves the heart protected against infarction even after the adenosine has been withdrawn. Expand
Opening of Mitochondrial KATP Channels Triggers the Preconditioned State by Generating Free Radicals
TLDR
Mito KATP channels are not the end effectors of protection, but rather their opening before ischemia generates free radicals that trigger entrance into a preconditioned state and activation of kinases, indicating that diazoxide triggers protection through free radicals. Expand
alpha 1-adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C.
TLDR
Alpha 1 receptors do not precondition through an adenosine intermediate but that alpha 1-adrenergic andAdenosine receptors activate parallel pathways within the myocyte that can trigger and mediate protection. Expand
Phosphorylation of tyrosine 182 of p38 mitogen-activated protein kinase correlates with the protection of preconditioning in the rabbit heart.
TLDR
It is concluded that p38 MAPK phosphorylation correlates with preconditioning's protection, and that its activation may be an important step in the signal transduction cascade of ischemic preconditionsing. Expand
Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning.
TLDR
The results suggest that the beneficial effect of exogenous NO production during SNAP pretreatment is mediated by a protein kinase C-dependent pathway via MPG-sensitive oxidants, and that any contribution of endogenous NO to classical PC's protection in isolated rabbit hearts is unable to be shown. Expand
Protein kinase C-epsilon is responsible for the protection of preconditioning in rabbit cardiomyocytes.
TLDR
It is indicated that PKC-epsilon alone is responsible for the early phase of PC's protection in rabbit cardiomyocytes and this study uses novel peptide inhibitors which correspond to part of the amino acid sequence from the isozyme-specific RACK-binding site on the PKC molecule. Expand
Evidence that the adenosine A3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart.
TLDR
Testing the hypothesis that the newly described A3 adenosine receptor, which has an agonist profile similar to the A1 receptor but is insensitive to DPCPX, might mediate preconditioning indicates that the protection of preconditionsing is not exclusively mediated by theAdenosine A1 receptors in rabbit heart and could involve the A3 receptor. Expand
Mild Hypothermia reduces infarct size in the beating rabbit heart: A practical intervention for acute myocardial infarction?
TLDR
Hypothermia might be a simple and useful therapy for patients presenting with acute myocardial infarction and added to the effect from ischemic preconditioning delayed the progressive increase in osmotic fragility that occurs during simulated ischemia in an additive way. Expand
Rat and rabbit heart infarction: effects of anesthesia, perfusate, risk zone, and method of infarct sizing.
TLDR
The relationship between risk zone and infarction was found to be remarkably independent of the model chosen, and the nonzero intercept for the rabbit heart can be an important, previously unrecognized source of experimental variability when infarct size is expressed as a percentage of the risk zone. Expand
...
1
2
3
...