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COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up
Biochemical markers of muscular damage
Total antioxidant status can be used to evaluate the level of stress in muscle by other markers, such as thiobarbituric acid-reactive substances, malondialdehyde, sulfhydril groups, reduced glutathione, oxidized glutathion, superoxide dismutase, catalase and others.
Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis
- B. Henry, M. H. S. de Oliveira, S. Benoit, M. Plebani, G. Lippi
- Medicine, BiologyClinical chemistry and laboratory medicine
- 10 April 2020
Several biomarkers which may potentially aid in risk stratification models for predicting severe and fatal COVID-19 were identified and clinicians are advised to closely monitor WBC count, lymphocyte count, platelet count, IL-6 and serum ferritin as markers for potential progression to critical illness.
Statins for Primary Prevention of Cardiovascular Disease.
Laboratory abnormalities in patients with COVID-2019 infection
The evidence that laboratory criteria for diagnosing DIC are present in nearly three-fourths of patients who died underscores the critical role of these tests in this and other clinical settings, thus suggesting that their assessment shall be considered a routine part of COVID-19 patient monitoring.
Acquired factor VIII inhibitors.
An analysis of the literature shows that the most effective first-line treatment for the eradication of factor VIII autoantibodies is the combination of steroids and cyclophosphamide, however, there is increasing evidence on the effectiveness of other treatment approaches, such as immune tolerance regimens and rituximab.
Red blood cell distribution width: A simple parameter with multiple clinical applications
- G. Salvagno, F. Sanchis-Gomar, A. Picanza, G. Lippi
- MedicineCritical reviews in clinical laboratory sciences
- 4 March 2015
The aim of this article is to provide general information about RDW and its routine assessment, to review the most relevant implications in health and disease and give some insights about its potential clinical applications.
Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis
Potential preanalytical and analytical vulnerabilities in the laboratory diagnosis of coronavirus disease 2019 (COVID-19)
Some practical indications can hence be identified for minimizing the risk of diagnostic errors, encompassing the improvement of diagnostic accuracy by combining clinical evidence with results of chest computed tomography and RT-PCR, and refinement of molecular target(s) and thorough compliance with analytical procedures, including quality assurance.
Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients.
- G. Lippi, G. Targher, M. Montagnana, G. Salvagno, G. Zoppini, G. Guidi
- MedicineArchives of pathology & laboratory medicine
- 20 October 2009
This study demonstrates for the first time a strong, graded association of RDW with hsCRP and ESR independent of numerous confounding factors, and might provide a rationale to introduce the easy, inexpensive RDW in algorithms for cardiovascular risk prediction.